Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition

Abstract Pregnancy-Associated Plasma Protein A isoforms, PAPP-A and PAPP-A2, are metalloproteases that cleave insulin-like growth factor binding proteins (IGFBPs) to modulate insulin-like growth factor signaling. The structures of homodimeric PAPP-A in complex with IGFBP5 anchor peptide, and inhibit...

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Bibliographic Details
Published in:Communications Chemistry
Main Authors: Janani Sridar, Amirhossein Mafi, Russell A. Judge, Jun Xu, Kailyn A. Kong, John C. K. Wang, Vincent S. Stoll, Georgios Koukos, Reyna J. Simon, Dan Eaton, Matthew Bratkowski, Qi Hao
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Online Access:https://doi.org/10.1038/s42004-023-01032-y

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https://doi.org/10.1038/s42004-023-01032-y

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