Folate receptor β performs an immune checkpoint function in activated macrophages

Monocytes and macrophages are sentinels of the immune system that distinguish themselves from other cells by expressing the beta isoform of the folate receptor (FRβ). Because FRβ does not bind folate until the monocyte/macrophage is exposed to immunosuppressive cytokines, the question naturally aros...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Fenghua Zhang, Md Yusuf Al-Amin, Sagar Utturkar, Rina Jiang, Gregory Cresswell, Rami Alfar, Ian Ophaug-Johansen, Gabriel Bachman, Madduri Srinivasarao, Richard Finnell, Amaya Puig-Kröger, Timothy Ratliff, Philip S. Low
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	immune checkpoint macrophages MDSCs (myeloid-derived suppressor cells) folate receptor beta (FRβ, Folr2) tumor-associated macrophages (TAMs) tumor microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638907/full