Novel energy optimizer, meldonium, rapidly restores acute hypobaric hypoxia-induced brain injury by targeting phosphoglycerate kinase 1

Abstract Background Acute hypobaric hypoxia-induced brain injury has been a challenge in the health management of mountaineers; therefore, new neuroprotective agents are urgently required. Meldonium, a well-known cardioprotective drug, has been reported to have neuroprotective effects. However, the...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Fengying Liu, Huanhuan He, Weijie Yang, Daohui Wang, Xin Sui, Yangyang Sun, Shuai Wang, Yi Yang, Zhenyu Xiao, Jun Yang, Yongan Wang, Yuan Luo
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Meldonium Hypobaric hypoxia Brain injury Energy metabolism Mitochondrial damage Phosphoglycerate kinase 1
Online Access:	https://doi.org/10.1186/s12964-024-01757-w