Nuclear Transglutaminase 2 interacts with topoisomerase II⍺ to promote DNA damage repair in lung cancer cells

Abstract Background To block repairs of DNA damages, especially the DNA double strand break (DSB) repair, can be used to induce cancer cell death. DSB repair depends on a sequential activation of DNA repair factors that may be potentially targeted for clinical cancer therapy. Up to now, many protein...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Xiao Lei, Kun Cao, Yuanyuan Chen, Hui Shen, Zhe Liu, Hongran Qin, Jianming Cai, Fu Gao, Yanyong Yang
Format:	Article
Language:	English
Published:	BMC 2021-07-01
Subjects:	DNA damage repair Transglutaminase 2 (TG2) DNA double strand breaks (DSBs) Topoisomerase IIα (TOPOIIα) Cancer therapy
Online Access:	https://doi.org/10.1186/s13046-021-02009-2