Automated monitoring of respiratory rate as a novel humane endpoint: A refinement in mouse metastatic lung cancer models.

In oncology research, while xenograft tumor models are easily visualized and humane endpoints can be clearly defined, metastatic tumor models are often based on more subjective clinical observations as endpoints. This study aimed at identifying objective non-invasive criteria for predicting imminent...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Caroline B Winn, Seo-Kyoung Hwang, Jeffrey Morin, Crystal T Bluette, Balasubramanian Manickam, Ziyue K Jiang, Anand Giddabasappa, Chang-Ning Liu, Kristin Matthews
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2021-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0257694