Activation of the intrinsic cell death pathway, increased apoptosis and modulation of astrocytes in the cerebellum of diabetic rats

Poorly controlled diabetes mellitus results in structural and functional changes in many brain regions. We demonstrate that in streptozotocin-induced diabetic rats cell death is increased and proliferation decreased in the cerebellum, indicating overall cell loss. Levels of both the proform and clea...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Alfonso M. Lechuga-Sancho, Ana I. Arroba, Laura M. Frago, Covadonga Pañeda, Cristina García-Cáceres, Arancha Delgado Rubín de Célix, Jesús Argente, Julie A. Chowen
Format:	Article
Language:	English
Published:	Elsevier 2006-08-01
Subjects:	Diabetes Cerebellum Apoptosis Caspase p53 Glia
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996106000593