Nanoparticle System Based on Amino-Dextran as a Drug Delivery Vehicle: Immune-Stimulatory CpG-Oligonucleotide Loading and Delivery

The aim of this study is to prepare and characterize an amino-dextran nanoparticle (aDNP) platform and investigate two loading strategies for unmethylated cytosine-phosphate-guanine (CpG) oligonucleotide. aDNP was prepared by desolvation of amino-dextran followed by the chemical crosslinking of amin...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Hien V. Nguyen, Katrin Campbell, Gavin F. Painter, Sarah L. Young, Greg F. Walker
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Subjects:
dextran nanoparticle
desolvation
vaccine formulation
CpG oligonucleotide
CpG adsorption
CpG conjugation
Online Access:https://www.mdpi.com/1999-4923/12/12/1150

Internet

https://www.mdpi.com/1999-4923/12/12/1150

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