Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria.

Clinical trials in severe falciparum malaria require a large sample size to detect clinically meaningful differences in mortality. This means few interventions can be evaluated at any time. Using a validated surrogate endpoint for mortality would provide a useful alternative allowing a smaller sampl...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Atthanee Jeeyapant, Hugh W Kingston, Katherine Plewes, Richard J Maude, Josh Hanson, M Trent Herdman, Stije J Leopold, Thatsanun Ngernseng, Prakaykaew Charunwatthana, Nguyen Hoan Phu, Aniruddha Ghose, M Mahtab Uddin Hasan, Caterina I Fanello, Md Abul Faiz, Tran Tinh Hien, Nicholas P J Day, Nicholas J White, Arjen M Dondorp
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-01-01
Online Access:	http://europepmc.org/articles/PMC5215574?pdf=render