LC–MS/MS method for the quantitation of decitabine and venetoclax in rat plasma after SPE: Application to pharmacokinetic study

This study developed a novel, sensitive and selective LC-MS/MS method for the concurrent determination of DCB and VTX in rat plasma using encorafenib as internal standard (IS). To identify DCB, VTX, and IS, the positive multiple reaction monitoring (MRM) mode was used. Chromatographic separation was...

Full description

Bibliographic Details

Published in:	Saudi Pharmaceutical Journal
Main Authors:	Abdulaziz I. Alnasser, Mohamed M. Hefnawy, Abdullah M. Al-Hossaini, Yousef A. Bin Jardan, Adel S. El-Azab, Alaa M. Abdel-Aziz, Abdulrahman M. Al-Obaid, Ibrahim A. Al-Suwaidan, Mohamed W. Attwa, Manal A. El-Gendy
Format:	Article
Language:	English
Published:	Springer 2023-09-01
Subjects:	LC–MS/MS Acute myeloid leukemia Decitabine Venetoclax Rat plasma Pharmacokinetics
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319016423001883