Comprehensive transcriptomic profiling reveals tissue-specific molecular signatures and dysregulated pathways in human diabetic foot ulcers

BackgroundDiabetic foot ulcers (DFUs) are a severe complication of diabetes mellitus characterized by impaired wound healing, chronic inflammation, and tissue degeneration. We sought to identify tissue specific molecular drivers of DFU pathogenesis across skin, adipose, and muscle compartments.Metho...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Guangrong Hu, Ayesha Nisar, Sawar Khan, Wen Li, Enfang Zhu, Haoling Cui, Guiqin Zhang, Yonghan He, Hui Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-11-01
Subjects:	diabetic foot ulcer diabetic associated complications transcriptomics of diabetic foot ulcer pathways of diabetic foot ulcer pathogenesis of diabetic foot ulcer
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1669205/full