Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund's adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, which is accompanied by progressive joint damage and disability. The intolerability of conventional antirheumatic drugs by some patients necessitates the search for effective antirheumatic agents having better tolerability. In the curr...

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Bibliographic Details

Published in:	Saudi Pharmaceutical Journal
Main Authors:	Amany A. Azouz, Esraa Saleh, Ali A. Abo-Saif
Format:	Article
Language:	English
Published:	Springer 2020-09-01
Subjects:	CFA-induced arthritis MMP-3 RANKL IL-6/JAK2/STAT3 signaling Aliskiren
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319016420301705