Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways

by Young Yun Jung, Muthu K. Shanmugam, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Published 2019-08-01

Potential Protective Effects of Ursolic Acid against Gamma Irradiation-Induced Damage Are Mediated through the Modulation of Diverse Inflammatory Mediators

by Hong Wang, Hong Wang, Meng-Kwoon Sim, Weng Keong Loke, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Feng Ru Tang, Gautam Sethi, Gautam Sethi, Gautam Sethi
Published 2017-06-01

Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study

by Apriliana Cahya Khayrani, Rafidha Irdiani, Reza Aditama, Diah Kartika Pratami, Kenny Lischer, Mohammad Javed Ansari, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Hesham S. Almoallim, Muhamad Sahlan
Published 2021-03-01

The Multifaceted Role of Curcumin in Cancer Prevention and Treatment

by Muthu K. Shanmugam, Grishma Rane, Madhu Mathi Kanchi, Frank Arfuso, Arunachalam Chinnathambi, M. E. Zayed, Sulaiman Ali Alharbi, Benny K. H. Tan, Alan Prem Kumar, Gautam Sethi
Published 2015-02-01

2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway

by Jeong-Hyeon Ko, Jae Hwi Lee, Sang Hoon Jung, Seok-Geun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Woong Mo Yang, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Published 2017-07-01

Identification of a novel 1,2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells

by Chaithanya Somu, Chakrabhavi Dhananjaya Mohan, Sachin Ambekar, Dukanya, Shobith Rangappa, CP Baburajeev, Alexey Sukhorukov, Srishti Mishra, Muthu K Shanmugam, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Basappa, Kanchugarakoppal S. Rangappa
Published 2020-03-01

Novel 1,3,4-oxadiazole Targets STAT3 Signaling to Induce Antitumor Effect in Lung Cancer

by Vikas H. Malojirao, Swamy S. Girimanchanaika, Muthu K. Shanmugam, Ankith Sherapura, Dukanya, Prashant K. Metri, Vellingiri Vigneshwaran, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Shobith Rangappa, Chakrabhavi Dhananjaya Mohan, Basappa, Bettadathunga T. Prabhakar, Kanchugarakoppal S. Rangappa
Published 2020-09-01

Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling...

by Hanwool Lee, Seung Ho Baek, Jong Hyun Lee, Chulwon Kim, Jeong-Hyeon Ko, Seok-Geun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Woong Mo Yang, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Published 2017-05-01

Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells

by Chakrabhavi Dhananjaya Mohan, Nirvanappa C. Anilkumar, Shobith Rangappa, Muthu K. Shanmugam, Srishti Mishra, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Atanu Bhattacharjee, Gautam Sethi, Alan Prem Kumar, Alan Prem Kumar, Basappa, Basappa, Kanchugarakoppal S. Rangappa
Published 2018-03-01

NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance

by Javadi Monisha, Nand Kishor Roy, Ganesan Padmavathi, Kishore Banik, Devivasha Bordoloi, Amrita Devi Khwairakpam, Frank Arfuso, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Gautam Sethi, Alan Prem Kumar, Ajaikumar B. Kunnumakkara
Published 2018-07-01

Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase

by Seung Ho Baek, Jong Hyun Lee, Chulwon Kim, Jeong-Hyeon Ko, Seung-Hee Ryu, Seok-Geun Lee, Woong Mo Yang, Jae-Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Gautam Sethi, Kwang Seok Ahn
Published 2017-02-01

Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway.

by Chakrabhavi Dhananjaya Mohan, V Srinivasa, Shobith Rangappa, Lewis Mervin, Surender Mohan, Shardul Paricharak, Sefer Baday, Feng Li, Muthu K Shanmugam, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Andreas Bender, Gautam Sethi, Basappa, Kanchugarakoppal S Rangappa
Published 2016-01-01

Correction: Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo.

by Anilkumar C Nirvanappa, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Hanumappa Ananda, Alexey Yu Sukhorukov, Muthu K Shanmugam, Mahalingam S Sundaram, Siddaiah Chandra Nayaka, Kesturu S Girish, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Gautam Sethi, Basappa, Kanchugarakoppal S Rangappa
Published 2017-01-01

Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo.

by Anilkumar C Nirvanappa, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Hanumappa Ananda, Alexey Yu Sukhorukov, Muthu K Shanmugam, Mahalingam S Sundaram, Siddaiah Chandra Nayaka, Kesturu S Girish, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Gautam Sethi, Basappa, Kanchugarakoppal S Rangappa
Published 2016-01-01

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma

by Jong Hyun Lee, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Young Yun Jung, Shobith Rangappa, Salundi Basappa, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Manoj Garg, Zhi-Xiu Lin, Kanchugarakoppal S. Rangappa, Gautam Sethi, Kam Man Hui, Kwang Seok Ahn
Published 2020-11-01

N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway

by Chakrabhavi Dhananjaya Mohan, Hanumantharayappa Bharathkumar, Dukanya, Shobith Rangappa, Muthu K. Shanmugam, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Atanu Bhattacharjee, Peter E. Lobie, Amudha Deivasigamani, Kam Man Hui, Gautam Sethi, Basappa, Basappa, Kanchugarakoppal S. Rangappa, Alan Prem Kumar, Alan Prem Kumar, Alan Prem Kumar, Alan Prem Kumar
Published 2018-11-01

Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis

by Muthu K. Shanmugam, Kwang Seok Ahn, Annie Hsu, Chern Chiuh Woo, Yi Yuan, Yi Yuan, Kwong Huat Benny Tan, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Angele Pei Fern Koh, Frank Arfuso, Ruby Yun-Ju Huang, Ruby Yun-Ju Huang, Ruby Yun-Ju Huang, Lina H. K. Lim, Lina H. K. Lim, Gautam Sethi, Alan Prem Kumar, Alan Prem Kumar, Alan Prem Kumar, Alan Prem Kumar, Alan Prem Kumar
Published 2018-12-01