Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses.

by Matthew Zirui Tay, Pinghuang Liu, LaTonya D Williams, Michael D McRaven, Sheetal Sawant, Thaddeus C Gurley, Thomas T Xu, S Moses Dennison, Hua-Xin Liao, Agnès-Laurence Chenine, S Munir Alam, M Anthony Moody, Thomas J Hope, Barton F Haynes, Georgia D Tomaras
Published 2016-08-01

HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 spec...

by Kelly E Seaton, Lamar Ballweber, Audrey Lan, Michele Donathan, Sean Hughes, Lucia Vojtech, M Anthony Moody, Hua-Xin Liao, Barton F Haynes, Christine G Galloway, Barbra A Richardson, Salim Abdool Karim, Charlene S Dezzutti, M Juliana McElrath, Georgia D Tomaras, Florian Hladik
Published 2014-01-01

Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.

by Barney S Graham, M Juliana McElrath, Michael C Keefer, Kyle Rybczyk, David Berger, Kent J Weinhold, Janet Ottinger, Guido Ferarri, David C Montefiori, Don Stablein, Carol Smith, Richard Ginsberg, John Eldridge, Ann Duerr, Pat Fast, Barton F Haynes, AIDS Vaccine Evaluation Group
Published 2010-08-01

HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth

by Chelsea N. Fries, Jui-Lin Chen, Maria L. Dennis, Nicole L. Votaw, Joshua Eudailey, Brian E. Watts, Kelly M. Hainline, Derek W. Cain, Richard Barfield, Cliburn Chan, M. Anthony Moody, Barton F. Haynes, Kevin O. Saunders, Sallie R. Permar, Genevieve G. Fouda, Joel H. Collier
Published 2021-07-01

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

by Qifeng Han, Julia A. Jones, Nathan I. Nicely, Rachel K. Reed, Xiaoying Shen, Katayoun Mansouri, Mark Louder, Ashley M. Trama, S. Munir Alam, Robert J. Edwards, Mattia Bonsignori, Georgia D. Tomaras, Bette Korber, David C. Montefiori, John R. Mascola, Michael S. Seaman, Barton F. Haynes, Kevin O. Saunders
Published 2019-07-01

Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing.

by Hui Li, Mark B Stoddard, Shuyi Wang, Lily M Blair, Elena E Giorgi, Erica H Parrish, Gerald H Learn, Peter Hraber, Paul A Goepfert, Michael S Saag, Thomas N Denny, Barton F Haynes, Beatrice H Hahn, Ruy M Ribeiro, Alan S Perelson, Bette T Korber, Tanmoy Bhattacharya, George M Shaw
Published 2012-01-01

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.

by Cinque Soto, Gilad Ofek, M Gordon Joyce, Baoshan Zhang, Krisha McKee, Nancy S Longo, Yongping Yang, Jinghe Huang, Robert Parks, Joshua Eudailey, Krissey E Lloyd, S Munir Alam, Barton F Haynes, NISC Comparative Sequencing Program, James C Mullikin, Mark Connors, John R Mascola, Lawrence Shapiro, Peter D Kwong
Published 2016-01-01

Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting.

by Lynn Morris, Xi Chen, Munir Alam, Georgia Tomaras, Ruijun Zhang, Dawn J Marshall, Bing Chen, Robert Parks, Andrew Foulger, Frederick Jaeger, Michele Donathan, Mira Bilska, Elin S Gray, Salim S Abdool Karim, Thomas B Kepler, John Whitesides, David Montefiori, M Anthony Moody, Hua-Xin Liao, Barton F Haynes
Published 2011-01-01

Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants

by Peter Hraber, Bette Korber, Kshitij Wagh, Elena E. Giorgi, Tanmoy Bhattacharya, S. Gnanakaran, Alan S. Lapedes, Gerald H. Learn, Edward F. Kreider, Yingying Li, George M. Shaw, Beatrice H. Hahn, David C. Montefiori, S. Munir Alam, Mattia Bonsignori, M. Anthony Moody, Hua-Xin Liao, Feng Gao, Barton F. Haynes
Published 2015-10-01

Correction: HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.

by Celia C LaBranche, Andrew T McGuire, Matthew D Gray, Shay Behrens, Xuejun Chen, Tongqing Zhou, Quentin J Sattentau, James Peacock, Amanda Eaton, Kelli Greene, Hongmei Gao, Haili Tang, Lautaro G Perez, Kevin O Saunders, Peter D Kwong, John R Mascola, Barton F Haynes, Leonidas Stamatatos, David C Montefiori
Published 2019-03-01

Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques

by Norbert Pardi, Celia C. LaBranche, Guido Ferrari, Derek W. Cain, István Tombácz, Robert J. Parks, Hiromi Muramatsu, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Patricia Polacino, Christopher J. Barbosa, Thomas D. Madden, Michael J. Hope, Barton F. Haynes, David C. Montefiori, Shiu-Lok Hu, Drew Weissman
Published 2019-04-01

A critical role for CD8 T cells in a nonhuman primate model of tuberculosis.

by Crystal Y Chen, Dan Huang, Richard C Wang, Ling Shen, Gucheng Zeng, Shuyun Yao, Yun Shen, Lisa Halliday, Jeff Fortman, Milton McAllister, Jim Estep, Robert Hunt, Daphne Vasconcelos, George Du, Steven A Porcelli, Michelle H Larsen, William R Jacobs, Barton F Haynes, Norman L Letvin, Zheng W Chen
Published 2009-04-01

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

by Raiees Andrabi, Jesper Pallesen, Joel D. Allen, Ge Song, Jinsong Zhang, Natalia de Val, Gavin Gegg, Katelyn Porter, Ching-Yao Su, Matthias Pauthner, Amanda Newman, Hilary Bouton-Verville, Fernando Garces, Ian A. Wilson, Max Crispin, Beatrice H. Hahn, Barton F. Haynes, Laurent Verkoczy, Andrew B. Ward, Dennis R. Burton
Published 2019-05-01

Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee

by Nathan I. Nicely, Kevin Wiehe, Thomas B. Kepler, Frederick H. Jaeger, S. Moses Dennison, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, Merlin L. Robb, Robert J. O'Connell, Nelson L. Michael, Jerome H. Kim, Hua-Xin Liao, S. Munir Alam, Kwan-Ki Hwang, Mattia Bonsignori, Barton F. Haynes
Published 2015-07-01

Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates.

by Joseph R Francica, Richard Laga, Geoffrey M Lynn, Gabriela Mužíková, Ladislav Androvič, Baptiste Aussedat, William E Walkowicz, Kartika Padhan, Ramiro Andrei Ramirez-Valdez, Robert Parks, Stephen D Schmidt, Barbara J Flynn, Yaroslav Tsybovsky, Guillaume B E Stewart-Jones, Kevin O Saunders, Faezzah Baharom, Constantinos Petrovas, Barton F Haynes, Robert A Seder
Published 2019-06-01

Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41.

by S Moses Dennison, Laura L Sutherland, Frederick H Jaeger, Kara M Anasti, Robert Parks, Shelley Stewart, Cindy Bowman, Shi-Mao Xia, Ruijun Zhang, Xiaoying Shen, Richard M Scearce, Gilad Ofek, Yongping Yang, Peter D Kwong, Sampa Santra, Hua-Xin Liao, Georgia Tomaras, Norman L Letvin, Bing Chen, S Munir Alam, Barton F Haynes
Published 2011-01-01

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.

by Korey R Demers, George Makedonas, Marcus Buggert, Michael A Eller, Sarah J Ratcliffe, Nilu Goonetilleke, Chris K Li, Leigh Anne Eller, Kathleen Rono, Lucas Maganga, Sorachai Nitayaphan, Hannah Kibuuka, Jean-Pierre Routy, Mark K Slifka, Barton F Haynes, Andrew J McMichael, Nicole F Bernard, Merlin L Robb, Michael R Betts
Published 2016-08-01

Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.

by Will Fischer, Vitaly V Ganusov, Elena E Giorgi, Peter T Hraber, Brandon F Keele, Thomas Leitner, Cliff S Han, Cheryl D Gleasner, Lance Green, Chien-Chi Lo, Ambarish Nag, Timothy C Wallstrom, Shuyi Wang, Andrew J McMichael, Barton F Haynes, Beatrice H Hahn, Alan S Perelson, Persephone Borrow, George M Shaw, Tanmoy Bhattacharya, Bette T Korber
Published 2010-08-01

Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.

by Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K P Liu, Emma L Turnbull, Jesus F Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D Tomaras, Barton F Haynes, Clive M Gray, Persephone Borrow, Mario Roederer, Andrew J McMichael, Kent J Weinhold
Published 2011-02-01

HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.

by Celia C LaBranche, Andrew T McGuire, Matthew D Gray, Shay Behrens, Peter D Kwong, Xuejun Chen, Tongqing Zhou, Quentin J Sattentau, James Peacock, Amanda Eaton, Kelli Greene, Hongmei Gao, Haili Tang, Lautaro G Perez, Xuejun Chen, Kevin O Saunders, Peter D Kwong, John R Mascola, Barton F Haynes, Leonidas Stamatatos, David C Montefiori
Published 2018-11-01