Soluble interleukin-6 receptor in patients with JAK2V617F somatic mutation and myeloproliferative neoplasm

by Christoph Garbers, Stefan Rose-John
Published 2020-05-01

Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation

by Juliane Lokau, Maria Agthe, Christoph Garbers
Published 2016-01-01

Two N-Linked Glycans Differentially Control Maturation, Trafficking and Proteolysis, but not Activity of the IL-11 Receptor

by Maria Agthe, Yvonne Garbers, Joachim Grötzinger, Christoph Garbers
Published 2018-03-01

Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma

by Juliane Lokau, Victor Schoeder, Johannes Haybaeck, Christoph Garbers
Published 2019-11-01

Perturbation of the Actin Cytoskeleton in Human Hepatoma Cells Influences Interleukin-6 (IL-6) Signaling, but Not Soluble IL-6 Receptor Generation or NF-κB Activation

by Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Published 2021-07-01

The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients

by Malena dos Santos Guilherme, Nicolai M. Stoye, Stefan Rose-John, Christoph Garbers, Andreas Fellgiebel, Kristina Endres
Published 2019-07-01

Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells.

by Juliane Lokau, Florian Kleinegger, Yvonne Garbers, Georg H Waetzig, Joachim Grötzinger, Stefan Rose-John, Johannes Haybaeck, Christoph Garbers
Published 2020-01-01

Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles

by Philipp Arnold, Wiebke Lückstädt, Wenjia Li, Inga Boll, Juliane Lokau, Christoph Garbers, Ralph Lucius, Stefan Rose-John, Christoph Becker-Pauly
Published 2020-05-01

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP

by Martin Sammel, Florian Peters, Juliane Lokau, Franka Scharfenberg, Ludwig Werny, Stefan Linder, Christoph Garbers, Stefan Rose-John, Christoph Becker-Pauly
Published 2019-07-01

Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R

by Antonin Gellrich, Franka Scharfenberg, Florian Peters, Martin Sammel, Ole Helm, Fred Armbrust, Frederike Schmidt, Juliane Lokau, Christoph Garbers, Susanne Sebens, Philipp Arnold, Christoph Becker-Pauly
Published 2021-10-01

Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35.

by Samadhi Aparicio-Siegmund, Jens M Moll, Juliane Lokau, Melanie Grusdat, Jutta Schröder, Svenja Plöhn, Stefan Rose-John, Joachim Grötzinger, Philipp A Lang, Jürgen Scheller, Christoph Garbers
Published 2014-01-01

IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell Function

by Jan P. Böttcher, Oliver Schanz, Christoph Garbers, Anne Zaremba, Silke Hegenbarth, Christian Kurts, Marc Beyer, Joachim L. Schultze, Wolfgang Kastenmüller, Stefan Rose-John, Percy A. Knolle
Published 2014-09-01

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

by Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga
Published 2019-11-01

Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice

by Lena Marie Westermann, Anke Baranowsky, Giorgia Di Lorenzo, Tatyana Danyukova, Jamie Soul, Jean-Marc Schwartz, Gretl Hendrickx, Michael Amling, Stefan Rose-John, Christoph Garbers, Thorsten Schinke, Sandra Pohl
Published 2021-02-01

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

by Niloufar Monhasery, Jens Moll, Carly Cuman, Manuel Franke, Larissa Lamertz, Rebecca Nitz, Boris Görg, Dieter Häussinger, Juliane Lokau, Doreen M. Floss, Roland Piekorz, Eva Dimitriadis, Christoph Garbers, Jürgen Scheller
Published 2016-07-01

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro

by Charlotte M. Flynn, Yvonne Garbers, Stefan Düsterhöft, Rielana Wichert, Juliane Lokau, Christian H. K. Lehmann, Diana Dudziak, Bernd Schröder, Christoph Becker-Pauly, Stefan Rose-John, Samadhi Aparicio-Siegmund, Christoph Garbers
Published 2020-12-01

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

by Claudia M. Wunderlich, P. Justus Ackermann, Anna Lena Ostermann, Petra Adams-Quack, Merly C. Vogt, My-Ly Tran, Alexei Nikolajev, Ari Waisman, Christoph Garbers, Sebastian Theurich, Jan Mauer, Nadine Hövelmeyer, F. Thomas Wunderlich
Published 2018-04-01

Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice

by Maria Agthe, Julian Brügge, Yvonne Garbers, Marieke Wandel, Birte Kespohl, Philipp Arnold, Charlotte M. Flynn, Juliane Lokau, Samadhi Aparicio-Siegmund, Christian Bretscher, Stefan Rose-John, Georg H. Waetzig, Tracy Putoczki, Joachim Grötzinger, Christoph Garbers
Published 2018-10-01

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

by Steffen Riethmueller, Prasath Somasundaram, Johanna C Ehlers, Chien-Wen Hung, Charlotte M Flynn, Juliane Lokau, Maria Agthe, Stefan Düsterhöft, Yijue Zhu, Joachim Grötzinger, Inken Lorenzen, Tomas Koudelka, Kosuke Yamamoto, Ute Pickhinke, Rielana Wichert, Christoph Becker-Pauly, Marisa Rädisch, Alexander Albrecht, Markus Hessefort, Dominik Stahnke, Carlo Unverzagt, Stefan Rose-John, Andreas Tholey, Christoph Garbers
Published 2017-01-01

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

by Mohamed I Saad, Sultan Alhayyani, Louise McLeod, Liang Yu, Mohammad Alanazi, Virginie Deswaerte, Ke Tang, Thierry Jarde, Julian A Smith, Zdenka Prodanovic, Michelle D Tate, Jesse J Balic, D Neil Watkins, Jason E Cain, Steven Bozinovski, Elizabeth Algar, Tomohiro Kohmoto, Hiromichi Ebi, Walter Ferlin, Christoph Garbers, Saleela Ruwanpura, Irit Sagi, Stefan Rose‐John, Brendan J Jenkins
Published 2019-04-01