Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential

by David R. Sibley, Kathryn D. Luderman, R. Benjamin Free, Lei Shi
Published 2021-05-01

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

by Ravi Kumar Verma, Ara M Abramyan, Mayako Michino, R Benjamin Free, David R Sibley, Jonathan A Javitch, J Robert Lane, Lei Shi
Published 2018-01-01

A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors

by Miriam E. Bocarsly, Daniel da Silva e Silva, Vanessa Kolb, Kathryn D. Luderman, Sannidhi Shashikiran, Marcelo Rubinstein, David R. Sibley, Lauren K. Dobbs, Veronica A. Alvarez
Published 2019-10-01

The Dopamine D5 Receptor Is Involved in Working Memory

by Gregory V. Carr, Gregory V. Carr, Gregory V. Carr, Federica Maltese, David R. Sibley, Daniel R. Weinberger, Daniel R. Weinberger, Daniel R. Weinberger, Francesco Papaleo, Francesco Papaleo
Published 2017-10-01

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

by Lani S. Chun, Rakesh H. Vekariya, R. Benjamin Free, Yun Li, Da-Ting Lin, Ping Su, Fang Liu, Yoon Namkung, Stephane A. Laporte, Amy E. Moritz, Jeffrey Aubé, Kevin J. Frankowski, David R. Sibley
Published 2018-02-01

Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

by Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R. Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W. Logan, Claes B. Wollheim, Massimo Trucco, Vijay K. Yechoor, David R. Sibley, Rita Bottino, Zachary Freyberg
Published 2021-02-01

High-potency ligands for DREADD imaging and activation in rodents and monkeys

by Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu, Juan L. Gomez, Marta Sanchez-Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, Christina Ruiz, Mitchell R. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, Ruin Moaddel, Patrick J. Morris, Lei Shi, David R. Sibley, Stephen V. Mahler, Sadegh Nabavi, Martin G. Pomper, Antonello Bonci, Andrew G. Horti, Barry J. Richmond, Michael Michaelides
Published 2019-10-01