The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitro

by Fabian Schumacher, Corinna Neuber, Hannah Finke, Kai Nieschalke, Jessica Baesler, Erich Gulbins, Burkhard Kleuser
Published 2017-08-01

Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides

by Jie Ma, Erich Gulbins, Michael J. Edwards, Charles C. Caldwell, Martin Fraunholz, Katrin Anne Becker
Published 2017-10-01

Role of Janus-Kinases in Major Depressive Disorder

by Anne Gulbins, Heike Grassmé, Richard Hoehn, Marcus Kohnen, Michael J. Edwards, Johannes Kornhuber, Erich Gulbins
Published 2016-08-01

Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.

by Dorothee Gramatzki, Caroline Herrmann, Caroline Happold, Katrin Anne Becker, Erich Gulbins, Michael Weller, Ghazaleh Tabatabai
Published 2013-01-01

Therapeutic Inhaled Sphingosine for Treating Lung Infection in a Mouse Model of Critical Illness

by Nadine Beckmann, Amanda M. Pugh, Nicholas J. Auteri, Michael J. Edwards, Erich Gulbins, Charles C. Caldwell
Published 2020-10-01

The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice

by Iulia Zoicas, Fabian Schumacher, Burkhard Kleuser, Martin Reichel, Erich Gulbins, Anna Fejtova, Johannes Kornhuber, Cosima Rhein
Published 2020-05-01

Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of Depression

by Christiane Mühle, Claudia Johanna Wagner, Katharina Färber, Tanja Richter-Schmidinger, Erich Gulbins, Bernd Lenz, Johannes Kornhuber
Published 2019-06-01

Characterization of acid sphingomyelinase activity in human cerebrospinal fluid.

by Christiane Mühle, Hagen B Huttner, Silke Walter, Martin Reichel, Fabio Canneva, Piotr Lewczuk, Erich Gulbins, Johannes Kornhuber
Published 2013-01-01

Sphingolipids in Major Depression

by Peter L. Jernigan, Richard S. Hoehn, Heike Grassmé, Michael J. Edwards, Christian P Müller, Johannes Kornhuber, Erich Gulbins
Published 2015-12-01

Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.

by Marwan Chami, Ramona Halmer, Laura Schnoeder, Katrin Anne Becker, Carola Meier, Klaus Fassbender, Erich Gulbins, Silke Walter
Published 2017-01-01

Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D

by Yuqing Wu, Cao Li, Huiming Peng, Ashraf Swaidan, Andrea Riehle, Barbara Pollmeier, Yang Zhang, Erich Gulbins, Heike Grassmé
Published 2020-11-01

Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development

by Yuetao Zhou, Madhuri S. Salker, Britta Walker, Patrick Münzer, Oliver Borst, Meinrad Gawaz, Erich Gulbins, Yogesh Singh, Florian Lang
Published 2016-08-01

The Common Acid Sphingomyelinase Polymorphism p.G508R is Associated with Self-Reported Allergy

by Martin Reichel, Tanja Richter-Schmidinger, Christiane Mühle, Cosima Rhein, Panagiotis Alexopoulos, Sibylle G. Schwab, Erich Gulbins, Johannes Kornhuber
Published 2014-06-01

Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline

by Constantin Adams, Vanya Icheva, Caroline Deppisch, Josefine Lauer, Gloria Herrmann, Ute Graepler-Mainka, Susanne Heyder, Erich Gulbins, Joachim Riethmueller
Published 2016-07-01

Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

by Susann Fayyaz, Lukasz Japtok, Fabian Schumacher, Dominik  Wigger, Tim Julius Schulz, Kathrin  Haubold, Erich Gulbins, Heinz  Völler, Burkhard Kleuser
Published 2017-09-01

Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide

by Anne Gulbins, Heike Grassmé, Richard Hoehn, Barbara Wilker, Matthias Soddemann, Marcus Kohnen, Michael J. Edwards, Johannes Kornhuber, Erich Gulbins
Published 2016-08-01

Sex-Dependent Decrease of Sphingomyelinase Activity During Alcohol Withdrawal Treatment

by Christiane Mühle, Violina Amova, Teresa Biermann, Kristina Bayerlein, Tanja Richter-Schmidinger, Thomas Kraus, Martin Reichel, Erich Gulbins, Johannes Kornhuber
Published 2014-06-01

Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage

by Richard S. Hoehn, Peter L. Jernigan, Alex L. Chang, Michael J. Edwards, Charles C. Caldwell, Erich Gulbins, Timothy A. Pritts
Published 2016-06-01

Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis

by Brent T. Xia, Nadine Beckmann, Leah K. Winer, Amanda M. Pugh, Timothy A. Pritts, Vanessa Nomellini, Erich Gulbins, Charles C. Caldwell
Published 2019-03-01

Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression

by Heike Grassmé, Peter L. Jernigan, Richard S. Hoehn, Barbara Wilker, Matthias Soddemann, Michael J. Edwards, Christian P. Müller, Johannes Kornhuber, Erich Gulbins
Published 2015-12-01