Identification of Estrogen Receptor α Antagonists from Natural Products via In Vitro and In Silico Approaches

by Xiaocong Pang, Weiqi Fu, Jinhua Wang, De Kang, Lvjie Xu, Ying Zhao, Ai-Lin Liu, Guan-Hua Du
Published 2018-01-01

Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment

by Mian Zu, Chao Li, Jian-Song Fang, Wen-Wen Lian, Ai-Lin Liu, Li-Shu Zheng, Guan-Hua Du
Published 2015-11-01

Anti-Inflammatory Activity of Methyl Salicylate Glycosides Isolated from Gaultheria yunnanensis (Franch.) Rehder

by Guan-Hua Du, Tian-Tai Zhang, Dong-Ming Zhang, Chao Wang, Chao Huang, Lan Sun, Rui Liu, Dan Zhang
Published 2011-05-01

Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulation

by Jiansong Fang, Ping Wu, Ranyao Yang, Li Gao, Chao Li, Dongmei Wang, Song Wu, Ai-Lin Liu, Guan-Hua Du
Published 2014-12-01

DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice

by Wenwen Lian, Jiansong Fang, Lvjie Xu, Wei Zhou, De Kang, Wandi Xiong, Hao Jia, Ai-Lin Liu, Guan-Hua Du
Published 2017-03-01

RKC-B1 Blocks Activation of NF-κB and NLRP3 Signaling Pathways to Suppress Neuroinflammation in LPS-Stimulated Mice

by Man Liu, Ying-Lin Yang, Shan-Shan Zhang, Dong-Ni Liu, Lian-Hua Fang, Guan-Hua Du, Yue-Hua Wang
Published 2021-07-01

A Novel Strategy for Decoding and Validating the Combination Principles of Huanglian Jiedu Decoction From Multi-Scale Perspective

by Ke-Xin Wang, Ke-Xin Wang, Yao Gao, Yao Gao, Wen-Xia Gong, Xiao-Feng Ye, Liu-Yi Fan, Chun Wang, Xue-Fei Gao, Li Gao, Guan-Hua Du, Guan-Hua Du, Xue-Mei Qin, Ai-Ping Lu, Dao-Gang Guan, Dao-Gang Guan
Published 2020-12-01

Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model

by YinZhong Ma, Li Li, LingLei Kong, ZhiMei Zhu, Wen Zhang, JunKe Song, Junlei Chang, GuanHua Du
Published 2018-01-01

Analysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type Interface

by Peng-Hui Yuan, Yan-Cai Bi, Bin Su, De-Zhi Yang, Ning-Bo Gong, Li Zhang, Yang Lu, Guan-Hua Du
Published 2020-05-01

AlzhCPI: A knowledge base for predicting chemical-protein interactions towards Alzheimer's disease.

by Jiansong Fang, Ling Wang, Yecheng Li, Wenwen Lian, Xiaocong Pang, Hong Wang, Dongsheng Yuan, Qi Wang, Ai-Lin Liu, Guan-Hua Du
Published 2017-01-01

Pinocembrin Protects Human Brain Microvascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPK/NF- κ B Inflammatory Pathways

by Rui Liu, Jin-ze Li, Jun-ke Song, Jia-lin Sun, Yong-jie Li, Si-bai Zhou, Tian-tai Zhang, Guan-hua Du
Published 2014-01-01

Network-Based Identification and Experimental Validation of Drug Candidates Toward SARS-CoV-2 via Targeting Virus–Host Interactome

by Jiansong Fang, Jiansong Fang, Qihui Wu, Fei Ye, Chuipu Cai, Lvjie Xu, Yong Gu, Qi Wang, Ai-lin Liu, Wenjie Tan, Guan-hua Du
Published 2021-09-01

Purity and Uncertainty Study of CRM Betulin by DSC

by Li Zhang, Peng-Hui Yuan, De-Zhi Yang, Yan-Cai Bi, Bin Su, Bao-Xi Zhang, Fu-Qing Wang, Yang Lu, Guan-Hua Du
Published 2020-08-01

A novel hypertensive crisis rat model established by excessive norepinephrine infusion and the potential therapeutic effects of Rho-kinase inhibitors on it

by Tian-Yi Yuan, Di Chen, Yu-Cai Chen, Hui-Fang Zhang, Zi-Ran Niu, Xiao-Zhen Jiao, Ping Xie, Lian-Hua Fang, Guan-Hua Du
Published 2019-01-01

Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice

by Wei-hua Jia, Nuo-qi Wang, Lin Yin, Xi Chen, Bi-yu Hou, Jin-hua Wang, Gui-fen Qiang, Chi Bun Chan, Xiu-ying Yang, Guan-hua Du
Published 2020-03-01

Chronic Urotensin-II Administration Improves Whole-Body Glucose Tolerance in High-Fat Diet-Fed Mice

by Xi Chen, Lin Yin, Wei-hua Jia, Nuo-qi Wang, Chun-yang Xu, Bi-yu Hou, Na Li, Li Zhang, Gui-fen Qiang, Xiu-ying Yang, Guan-hua Du
Published 2019-07-01