Integrated Clarification and Purification of Monoclonal Antibodies by Membrane Based Separation of Aqueous Two-Phase Systems

by Thomas Kruse, Axel Schmidt, Markus Kampmann, Jochen Strube
Published 2019-07-01

Advanced Process Analytical Technology in Combination with Process Modeling for Endpoint and Model Parameter Determination in Lyophilization Process Design and Optimization

by Alex Juckers, Petra Knerr, Frank Harms, Jochen Strube
Published 2021-09-01

PAT for Continuous Chromatography Integrated into Continuous Manufacturing of Biologics towards Autonomous Operation

by Florian Lukas Vetter, Steffen Zobel-Roos, Jochen Strube
Published 2021-03-01

Distinct and Quantitative Validation Method for Predictive Process Modelling in Preparative Chromatography of Synthetic and Bio-Based Feed Mixtures Following a Quality-by-Design (Q...

by Steffen Zobel-Roos, Mourad Mouellef, Reinhard Ditz, Jochen Strube
Published 2019-09-01

Process Analytical Approach towards Quality Controlled Process Automation for the Downstream of Protein Mixtures by Inline Concentration Measurements Based on Ultraviolet/Visible L...

by Steffen Zobel-Roos, Mourad Mouellef, Christian Siemers, Jochen Strube
Published 2017-12-01

Digital Twin for Lyophilization by Process Modeling in Manufacturing of Biologics

by Leon S. Klepzig, Alex Juckers, Petra Knerr, Frank Harms, Jochen Strube
Published 2020-10-01

Purification of Monoclonal Antibodies Using a Fiber Based Cation-Exchange Stationary Phase: Parameter Determination and Modeling

by Jan Schwellenbach, Steffen Zobel, Florian Taft, Louis Villain, Jochen Strube
Published 2016-10-01

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part III: Chromatographic Purification

by Fabian Mestmäcker, Axel Schmidt, Maximilian Huter, Maximilian Sixt, Jochen Strube
Published 2018-10-01

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

by Maximilian Johannes Huter, Axel Schmidt, Fabian Mestmäcker, Maximilian Sixt, Jochen Strube
Published 2018-10-01

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part II: Model-Based Design of Agitated and Packed Columns f...

by Axel Schmidt, Maximilian Sixt, Maximilian Johannes Huter, Fabian Mestmäcker, Jochen Strube
Published 2018-10-01

Digital Twin of mRNA-Based SARS-COVID-19 Vaccine Manufacturing towards Autonomous Operation for Improvements in Speed, Scale, Robustness, Flexibility and Real-Time Release Testing

by Axel Schmidt, Heribert Helgers, Florian Lukas Vetter, Alex Juckers, Jochen Strube
Published 2021-04-01

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part I: Conceptual Process Design and Cost Estimation

by Maximilian Sixt, Axel Schmidt, Fabian Mestmäcker, Maximilian Johannes Huter, Lukas Uhlenbrock, Jochen Strube
Published 2018-09-01

Natural Products Extraction of the Future—Sustainable Manufacturing Solutions for Societal Needs

by Lukas Uhlenbrock, Maximilian Sixt, Martin Tegtmeier, Hartwig Schulz, Hansjörg Hagels, Reinhard Ditz, Jochen Strube
Published 2018-10-01

Host Cell Proteins in Biologics Manufacturing: The Good, the Bad, and the Ugly

by Martin Kornecki, Fabian Mestmäcker, Steffen Zobel-Roos, Laura Heikaus de Figueiredo, Hartmut Schlüter, Jochen Strube
Published 2017-09-01

Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing

by Martin Kornecki, Axel Schmidt, Lara Lohmann, Maximilian Huter, Fabian Mestmäcker, Leon Klepzig, Mourad Mouellef, Steffen Zobel-Roos, Jochen Strube
Published 2019-08-01

Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody Manufacturing

by Heribert Helgers, Axel Schmidt, Lara Julia Lohmann, Florian Lukas Vetter, Alex Juckers, Christoph Jensch, Mourad Mouellef, Steffen Zobel-Roos, Jochen Strube
Published 2021-01-01

Accelerating Biologics Manufacturing by Modeling or: Is Approval under the QbD and PAT Approaches Demanded by Authorities Acceptable without a Digital-Twin?

by Steffen Zobel-Roos, Axel Schmidt, Fabian Mestmäcker, Mourad Mouellef, Maximilian Huter, Lukas Uhlenbrock, Martin Kornecki, Lara Lohmann, Reinhard Ditz, Jochen Strube
Published 2019-02-01