Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells[S]

by Nicolas J. Pillon, Scott Frendo-Cumbo, Maya R. Jacobson, Zhi Liu, Paul L. Milligan, Hai Hoang Bui, Juleen R. Zierath, Philip J. Bilan, Joseph T. Brozinick, Amira Klip
Published 2018-01-01

Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health

by Kristine Williams, Germán D. Carrasquilla, Lars Roed Ingerslev, Mette Yde Hochreuter, Svenja Hansson, Nicolas J. Pillon, Ida Donkin, Soetkin Versteyhe, Juleen R. Zierath, Tuomas O. Kilpeläinen, Romain Barrès
Published 2021-11-01

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

by Thais de Castro Barbosa, Lars R. Ingerslev, Petter S. Alm, Soetkin Versteyhe, Julie Massart, Morten Rasmussen, Ida Donkin, Rasmus Sjögren, Jonathan M. Mudry, Laurène Vetterli, Shashank Gupta, Anna Krook, Juleen R. Zierath, Romain Barrès
Published 2016-03-01

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

by Jorge C. Correia, Julie Massart, Jan Freark de Boer, Margareta Porsmyr-Palmertz, Vicente Martínez-Redondo, Leandro Z. Agudelo, Indranil Sinha, David Meierhofer, Vera Ribeiro, Marie Björnholm, Sascha Sauer, Karin Dahlman-Wright, Juleen R. Zierath, Albert K. Groen, Jorge L. Ruas
Published 2015-12-01

TXNIP regulates peripheral glucose metabolism in humans.

by Hemang Parikh, Emma Carlsson, William A Chutkow, Lovisa E Johansson, Heidi Storgaard, Pernille Poulsen, Richa Saxena, Christine Ladd, P Christian Schulze, Michael J Mazzini, Christine Bjørn Jensen, Anna Krook, Marie Björnholm, Hans Tornqvist, Juleen R Zierath, Martin Ridderstråle, David Altshuler, Richard T Lee, Allan Vaag, Leif C Groop, Vamsi K Mootha
Published 2007-05-01

ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.

by Ellen Markljung, Lin Jiang, Jacob D Jaffe, Tarjei S Mikkelsen, Ola Wallerman, Martin Larhammar, Xiaolan Zhang, Li Wang, Veronica Saenz-Vash, Andreas Gnirke, Anders M Lindroth, Romain Barrés, Jie Yan, Sara Strömberg, Sachinandan De, Fredrik Pontén, Eric S Lander, Steven A Carr, Juleen R Zierath, Klas Kullander, Claes Wadelius, Kerstin Lindblad-Toh, Göran Andersson, Göran Hjälm, Leif Andersson
Published 2009-12-01

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

by Luca A Lotta, Robert A Scott, Stephen J Sharp, Stephen Burgess, Jian'an Luan, Therese Tillin, Amand F Schmidt, Fumiaki Imamura, Isobel D Stewart, John R B Perry, Luke Marney, Albert Koulman, Edward D Karoly, Nita G Forouhi, Rasmus J O Sjögren, Erik Näslund, Juleen R Zierath, Anna Krook, David B Savage, Julian L Griffin, Nishi Chaturvedi, Aroon D Hingorani, Kay-Tee Khaw, Inês Barroso, Mark I McCarthy, Stephen O'Rahilly, Nicholas J Wareham, Claudia Langenberg
Published 2016-11-01