Biophysical detection of diversity and bias in GPCR function

by Werner eJaeger, Stephen eArmstrong, Stephen eHill, Kevin D G Pfleger, Kevin D G Pfleger
Published 2014-03-01

NanoBRET: The Bright Future of Proximity-Based Assays

by Natasha C. Dale, Natasha C. Dale, Natasha C. Dale, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Carl W. White, Carl W. White, Carl W. White, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger
Published 2019-03-01

Experimental determination of the bioluminescence resonance energy transfer (BRET) Förster distances of NanoBRET and red-shifted BRET pairs

by Felix Weihs, Jian Wang, Kevin D.G. Pfleger, Helen Dacres
Published 2020-11-01

A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding

by Carl W. White, Laura E. Kilpatrick, Kevin D.G. Pfleger, Stephen J. Hill
Published 2021-01-01

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression.

by Natália G Sampaio, Martina Kocan, Louis Schofield, Kevin D G Pfleger, Emily M Eriksson
Published 2018-01-01

Profiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology.

by Mohammed Akli Ayoub, Heng B See, Ruth M Seeber, Stephen P Armstrong, Kevin D G Pfleger
Published 2013-01-01

Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V).

by Stephen P Armstrong, Ruth M Seeber, Mohammed Akli Ayoub, Brian J Feldman, Kevin D G Pfleger
Published 2013-01-01

Using nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time

by Carl W. White, Hannah K. Vanyai, Heng B. See, Elizabeth K. M. Johnstone, Kevin D. G. Pfleger
Published 2017-06-01

Investigation of Receptor Heteromers Using NanoBRET Ligand Binding

by Elizabeth K. M. Johnstone, Heng B. See, Rekhati S. Abhayawardana, Angela Song, K. Johan Rosengren, Stephen J. Hill, Kevin D. G. Pfleger
Published 2021-01-01

Insights into the Interaction of LVV-Hemorphin-7 with Angiotensin II Type 1 Receptor

by Amanat Ali, Elizabeth K.M. Johnstone, Bincy Baby, Heng B. See, Angela Song, K. Johan Rosengren, Kevin D. G. Pfleger, Mohammed Akli Ayoub, Ranjit Vijayan
Published 2021-12-01

Deleterious GRM1 mutations in schizophrenia.

by Mohammed Akli Ayoub, Dora Angelicheva, David Vile, David Chandler, Bharti Morar, Juleen A Cavanaugh, Peter M Visscher, Assen Jablensky, Kevin D G Pfleger, Luba Kalaydjieva
Published 2012-01-01

Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease.

by Mohammed Akli Ayoub, Yuan Zhang, Robyn S Kelly, Heng B See, Elizabeth K M Johnstone, Elizabeth A McCall, James H Williams, Darren J Kelly, Kevin D G Pfleger
Published 2015-01-01

Homogeneous Time-Resolved Fluorescence-Based Assay to Monitor Extracellular Signal-Regulated Kinase Signalling in a High-Throughput Format

by Mohammed Akli eAyoub, Julien eTrebaux, Julie eVallaghe, Fabienne eCharrier-Savournin, Khaled eAl-Hosaini, Arturo eGonzalez-Moya, Jean-Philippe R Pin, Kevin D G Pfleger, Eric eTrinquet
Published 2014-06-01

The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer

by Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern, Pilar Blancafort
Published 2021-03-01