In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE

by Ko Willems van Dijk, Bart J.M. van Vlijmen, H. Belinda van't Hof, Andre van der Zee, Silvia Santamarina-Fojo, Theo J.C. van Berkel, Louis M. Havekes, Marten H. Hofker
Published 1999-02-01

ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency*

by Gery Gerritsen, Caroline C. van der Hoogt, Frank G. Schaap, Peter J. Voshol, Kyriakos E. Kypreos, Nobuyo Maeda, Albert K. Groen, Louis M. Havekes, Patrick C.N. Rensen, Ko Willems van Dijk
Published 2008-05-01

Znf202 affects high density lipoprotein cholesterol levels and promotes hepatosteatosis in hyperlipidemic mice.

by Carlos L J Vrins, Ruud Out, Peter van Santbrink, André van der Zee, Tokameh Mahmoudi, Martine Groenendijk, Louis M Havekes, Theo J C van Berkel, Ko Willems van Dijk, Erik A L Biessen
Published 2013-01-01

A Workflow for Missing Values Imputation of Untargeted Metabolomics Data

by Tariq Faquih, Maarten van Smeden, Jiao Luo, Saskia le Cessie, Gabi Kastenmüller, Jan Krumsiek, Raymond Noordam, Diana van Heemst, Frits R. Rosendaal, Astrid van Hylckama Vlieg, Ko Willems van Dijk, Dennis O. Mook-Kanamori
Published 2020-11-01

Correction to: Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a f...

by Elske L. van den Burg, Marjolein P. Schoonakker, Petra G. van Peet, M. Elske. van den Akker-van Marle, Ko Willems van Dijk, Valter D. Longo, Hildo J. Lamb, Mattijs E. Numans, Hanno Pijl
Published 2020-11-01

Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimickin...

by Elske L. van den Burg, Marjolein P. Schoonakker, Petra G. van Peet, M. Elske. van den Akker-van Marle, Ko Willems van Dijk, Valter D. Longo, Hildo J. Lamb, Mattijs E. Numans, Hanno Pijl
Published 2020-06-01

BMT decreases HFD-induced weight gain associated with decreased preadipocyte number and insulin secretion.

by Saeed Katiraei, Lisa R Hoving, Lianne van Beek, Sharida Mohamedhoesein, Françoise Carlotti, Janna A van Diepen, Patrick C N Rensen, Mihai G Netea, Ko Willems van Dijk, Jimmy F P Berbée, Vanessa van Harmelen
Published 2017-01-01

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

by Leon G. Martens, Jiao Luo, Fleur L. Meulmeester, Nadia Ashrafi, Esther Winters van Eekelen, Renée de Mutsert, Dennis O. Mook-Kanamori, Frits R. Rosendaal, Ko Willems van Dijk, Kevin Mills, Raymond Noordam, Diana van Heemst
Published 2020-12-01

In vivo and in silico dynamics of the development of Metabolic Syndrome.

by Yvonne J W Rozendaal, Yanan Wang, Yared Paalvast, Lauren L Tambyrajah, Zhuang Li, Ko Willems van Dijk, Patrick C N Rensen, Jan A Kuivenhoven, Albert K Groen, Peter A J Hilbers, Natal A W van Riel
Published 2018-06-01

Proteomic analysis in type 2 diabetes patients before and after a very low calorie diet reveals potential disease state and intervention specific biomarkers.

by Maria A Sleddering, Albert J Markvoort, Harish K Dharuri, Skhandhan Jeyakar, Marieke Snel, Peter Juhasz, Moira Lynch, Wade Hines, Xiaohong Li, Ingrid M Jazet, Aram Adourian, Peter A J Hilbers, Johannes W A Smit, Ko Willems Van Dijk
Published 2014-01-01

The hepatic uptake of VLDL in lrp−ldlr−/−vldlr−/− mice is regulated by LPL activity and involves proteoglycans and SR-BI

by Lihui Hu, Caroline C. van der Hoogt, Sonia M.S. Espirito Santo, Ruud Out, Kyriakos E. Kypreos, Bart J.M. van Vlijmen, Theo J.C. Van Berkel, Johannes A. Romijn, Louis M. Havekes, Ko Willems van Dijk, Patrick C.N. Rensen
Published 2008-07-01

Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9[S]

by Sam J.L. van der Tuin, Susan Kühnast, Jimmy F.P. Berbée, Lars Verschuren, Elsbet J. Pieterman, Louis M. Havekes, José W.A. van der Hoorn, Patrick C.N. Rensen, J. Wouter Jukema, Hans M.G. Princen, Ko Willems van Dijk, Yanan Wang
Published 2015-11-01

Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.

by Ayşe Demirkan, Peter Henneman, Aswin Verhoeven, Harish Dharuri, Najaf Amin, Jan Bert van Klinken, Lennart C Karssen, Boukje de Vries, Axel Meissner, Sibel Göraler, Arn M J M van den Maagdenberg, André M Deelder, Peter A C 't Hoen, Cornelia M van Duijn, Ko Willems van Dijk
Published 2015-01-01

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

by Aafke W.F. Janssen, Tom Houben, Saeed Katiraei, Wieneke Dijk, Lily Boutens, Nieke van der Bolt, Zeneng Wang, J. Mark Brown, Stanley L. Hazen, Stéphane Mandard, Ronit Shiri-Sverdlov, Folkert Kuipers, Ko Willems van Dijk, Jacques Vervoort, Rinke Stienstra, Guido J.E.J. Hooiveld, Sander Kersten
Published 2017-07-01

Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion[S]

by Janna A. van Diepen, Rinke Stienstra, Irene O. C.M. Vroegrijk, Sjoerd A.A. van den Berg, Daniela Salvatori, Guido J. Hooiveld, Sander Kersten, Cees J. Tack, Mihai G. Netea, Johannes W.A. Smit, Leo A.B. Joosten, Louis M. Havekes, Ko Willems van Dijk, Patrick C.N. Rensen
Published 2013-02-01

BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.

by Mariëtte R Boon, Sjoerd A A van den Berg, Yanan Wang, Jan van den Bossche, Sofia Karkampouna, Matthias Bauwens, Marijke De Saint-Hubert, Geertje van der Horst, Slobodan Vukicevic, Menno P J de Winther, Louis M Havekes, J Wouter Jukema, Jouke T Tamsma, Gabri van der Pluijm, Ko Willems van Dijk, Patrick C N Rensen
Published 2013-01-01

Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

by Fiona A. Hagenbeek, René Pool, Jenny van Dongen, H. M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J. C. N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka Suchiman, Marian Beekman, P. Eline Slagboom, Cornelia M. van Duijn, BBMRI Metabolomics Consortium, Amy C. Harms, Thomas Hankemeier, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Published 2020-03-01

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

by Fiona A. Hagenbeek, René Pool, Jenny van Dongen, Harmen H. M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J. C. N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka Suchiman, Marian Beekman, P. Eline Slagboom, Cornelia M. van Duijn, BBMRI Metabolomics Consortium, Amy C. Harms, Thomas Hankemeier, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Published 2020-01-01

A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening

by Rosa van den Berg, Sander Kooijman, Raymond Noordam, Ashna Ramkisoensing, Gustavo Abreu-Vieira, Lauren L. Tambyrajah, Wieneke Dijk, Philip Ruppert, Isabel M. Mol, Barbara Kramar, Rosanna Caputo, Laura Sardón Puig, Evelien M. de Ruiter, Jan Kroon, Menno Hoekstra, Ronald J. van der Sluis, Onno C. Meijer, Ko Willems van Dijk, Linda W.M. van Kerkhof, Constantinos Christodoulides, Fredrik Karpe, Zachary Gerhart-Hines, Sander Kersten, Johanna H. Meijer, Claudia P. Coomans, Diana van Heemst, Nienke R. Biermasz, Patrick C.N. Rensen
Published 2018-03-01

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

by Johannes Kettunen, Ayşe Demirkan, Peter Würtz, Harmen H.M. Draisma, Toomas Haller, Rajesh Rawal, Anika Vaarhorst, Antti J. Kangas, Leo-Pekka Lyytikäinen, Matti Pirinen, René Pool, Antti-Pekka Sarin, Pasi Soininen, Taru Tukiainen, Qin Wang, Mika Tiainen, Tuulia Tynkkynen, Najaf Amin, Tanja Zeller, Marian Beekman, Joris Deelen, Ko Willems van Dijk, Tõnu Esko, Jouke-Jan Hottenga, Elisabeth M van Leeuwen, Terho Lehtimäki, Evelin Mihailov, Richard J. Rose, Anton J.M. de Craen, Christian Gieger, Mika Kähönen, Markus Perola, Stefan Blankenberg, Markku J. Savolainen, Aswin Verhoeven, Jorma Viikari, Gonneke Willemsen, Dorret I. Boomsma, Cornelia M. van Duijn, Johan Eriksson, Antti Jula, Marjo-Riitta Järvelin, Jaakko Kaprio, Andres Metspalu, Olli Raitakari, Veikko Salomaa, P. Eline Slagboom, Melanie Waldenberger, Samuli Ripatti, Mika Ala-Korpela
Published 2016-03-01