The Novel Cognitive Enhancer ST101 Enhances Acetylcholine Release in Mouse Dorsal Hippocampus Through T-type Voltage-Gated Calcium Channel Stimulation

by Yui Yamamoto, Norifumi Shioda, Feng Han, Shigeki Moriguchi, Kohji Fukunaga
Published 2013-01-01

Analysis of binding affinity and docking of novel fatty acid-binding protein (FABP) ligands

by Yasuharu Shinoda, Yifei Wang, Tetsunori Yamamoto, Hiroyuki Miyachi, Kohji Fukunaga
Published 2020-08-01

T-type Ca2+ channel enhancer SAK3 administration improves the BPSD-like behaviors in AppNL−G-F/NL−G-F knock-in mice

by Tomohide Degawa, Ichiro Kawahata, Hisanao Izumi, Yasuharu Shinoda, Kohji Fukunaga
Published 2021-05-01

Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice

by Dian Yuan, An Cheng, Ichiro Kawahata, Hisanao Izumi, Jing Xu, Kohji Fukunaga
Published 2021-01-01

SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App^{NL-G-F/NL-G-F} Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling

by Hisanao Izumi, Ichiro Kawahata, Yasuharu Shinoda, Fred J. Helmstetter, Kohji Fukunaga
Published 2020-05-01

Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice

by Kazuya Matsuo, Yasushi Yabuki, Ronald Melki, Luc Bousset, Yuji Owada, Kohji Fukunaga
Published 2021-01-01

Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels

by Kohji Fukunaga, Hisanao Izumi, Yasushi Yabuki, Yasuharu Shinoda, Norifumi Shioda, Feng Han
Published 2019-02-01

SA4503, A Potent Sigma-1 Receptor Ligand, Ameliorates Synaptic Abnormalities and Cognitive Dysfunction in a Mouse Model of ATR-X Syndrome

by Kouya Yamaguchi, Norifumi Shioda, Yasushi Yabuki, Chen Zhang, Feng Han, Kohji Fukunaga
Published 2018-09-01

Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction

by Yasuharu Shinoda, Hideaki Tagashira, Md. Shenuarin Bhuiyan, Hideyuki Hasegawa, Hiroshi Kanai, Kohji Fukunaga
Published 2016-07-01

Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency

by Chinnasamy Dhanalakshmi, Udaiyappan Janakiraman, Aubin Moutal, Kohji Fukunaga, Rajesh Khanna, Mark A. Nelson
Published 2021-02-01

Correction: Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice

by Shigeki Moriguchi, Yasuharu Shinoda, Yui Yamamoto, Yuzuru Sasaki, Kosuke Miyajima, Hideaki Tagashira, Kohji Fukunaga
Published 2014-01-01

Cytoprotective Effect of 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl] ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e) Against Isc...

by Masami Hashimoto, Yoko Takada, Yusuke Takeuchi, Jiro Kasahara, Hiroaki Hisa, Yasufumi Shirasaki, Kohji Fukunaga
Published 2005-01-01

The Post-ischemic Administration of 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e),...

by Akihito Hashiguchi, Shigetoshi Yano, Motohiro Morioka, Junichiro Hamada, Yasufumi Shirasaki, Masato Kochi, Kohji Fukunaga
Published 2004-01-01

Correction: Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice.

by Shigeki Moriguchi, Yasuharu Shinoda, Yui Yamamoto, Yuzuru Sasaki, Kosuke Miyajima, Hideaki Tagashira, Kohji Fukunaga
Published 2014-01-01

Stimulation of the sigma-1 receptor by DHEA enhances synaptic efficacy and neurogenesis in the hippocampal dentate gyrus of olfactory bulbectomized mice.

by Shigeki Moriguchi, Yasuharu Shinoda, Yui Yamamoto, Yuzuru Sasaki, Kosuke Miyajima, Hideaki Tagashira, Kohji Fukunaga
Published 2013-01-01

Fatty Acid-Binding Proteins Aggravate Cerebral Ischemia-Reperfusion Injury in Mice

by Qingyun Guo, Ichiro Kawahata, Tomohide Degawa, Yuri Ikeda-Matsuo, Meiling Sun, Feng Han, Kohji Fukunaga
Published 2021-05-01

Combined citicoline and docosahexaenoic acid treatment improves cognitive dysfunction following transient brain ischemia

by Eri Nakazaki, Yasushi Yabuki, Hisanao Izumi, Yasuharu Shinoda, Fumiko Watanabe, Yukihiro Hishida, Ayako Kamimura, Kohji Fukunaga
Published 2019-04-01

CaMKIIδB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart.

by Ying-Mei Lu, Jiyun Huang, Norifumi Shioda, Kohji Fukunaga, Yasufumi Shirasaki, Xiao-Ming Li, Feng Han
Published 2011-01-01

Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect

by Satoru Tamura, Maiko Okada, Shigeaki Kato, Yasuharu Shinoda, Norifumi Shioda, Kohji Fukunaga, Kumiko Ui-Tei, Minoru Ueda
Published 2018-02-01

Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression.

by Yasuharu Shinoda, Hideaki Tagashira, Md Shenuarin Bhuiyan, Hideyuki Hasegawa, Hiroshi Kanai, Chen Zhang, Feng Han, Kohji Fukunaga
Published 2016-01-01