An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo

by Silvia Márquez-Jurado, Aitor Nogales, Ginés Ávila-Pérez, Francisco J. Iborra, Luis Martínez-Sobrido, Fernando Almazán
Published 2018-10-01

Natural Selection of H5N1 Avian Influenza A Viruses with Increased PA-X and NS1 Shutoff Activity

by Aitor Nogales, Laura Villamayor, Sergio Utrilla-Trigo, Javier Ortego, Luis Martinez-Sobrido, Marta L. DeDiego
Published 2021-09-01

Replication-Competent ΔNS1 Influenza A Viruses Expressing Reporter Genes

by Aitor Nogales, Michael Schotsaert, Raveen Rathnasinghe, Marta L. DeDiego, Adolfo García-Sastre, Luis Martinez-Sobrido
Published 2021-04-01

A New Master Donor Virus for the Development of Live-Attenuated Influenza B Virus Vaccines

by Chantelle L. White, Kevin Chiem, Daniel R. Perez, Jefferson Santos, Stivalis Cardenas Garcia, Aitor Nogales, Luis Martínez-Sobrido
Published 2021-06-01

Potent Inhibition of Zika Virus Replication by Aurintricarboxylic Acid

by Jun-Gyu Park, Ginés Ávila-Pérez, Ferralita Madere, Thomas A. Hilimire, Aitor Nogales, Fernando Almazán, Luis Martínez-Sobrido
Published 2019-04-01

Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR.

by Bianca Dauber, Luis Martínez-Sobrido, Jana Schneider, Rong Hai, Zoe Waibler, Ulrich Kalinke, Adolfo García-Sastre, Thorsten Wolff
Published 2009-06-01

A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide

by Thiruselvam Viswanathan, Anurag Misra, Siu-Hong Chan, Shan Qi, Nan Dai, Shailee Arya, Luis Martinez-Sobrido, Yogesh K. Gupta
Published 2021-06-01

A Bivalent Live-Attenuated Vaccine for the Prevention of Equine Influenza Virus

by Pilar Blanco-Lobo, Laura Rodriguez, Stephanie Reedy, Fatai S. Oladunni, Aitor Nogales, Pablo R. Murcia, Thomas M. Chambers, Luis Martinez-Sobrido
Published 2019-10-01

Identification of Inhibitors of ZIKV Replication

by Desarey Morales Vasquez, Jun-Gyu Park, Ginés Ávila-Pérez, Aitor Nogales, Juan Carlos de la Torre, Fernando Almazan, Luis Martinez-Sobrido
Published 2020-09-01

A Broad and Potent H1-Specific Human Monoclonal Antibody Produced in Plants Prevents Influenza Virus Infection and Transmission in Guinea Pigs

by Jun-Gyu Park, Chengjin Ye, Michael S. Piepenbrink, Aitor Nogales, Haifeng Wang, Michael Shuen, Ashley J. Meyers, Luis Martinez-Sobrido, James J. Kobie
Published 2020-02-01

Broad and Protective Influenza B Virus Neuraminidase Antibodies in Humans after Vaccination and their Clonal Persistence as Plasma Cells

by Michael S. Piepenbrink, Aitor Nogales, Madhubanti Basu, Christopher F. Fucile, Jane L. Liesveld, Michael C. Keefer, Alexander F. Rosenberg, Luis Martinez-Sobrido, James J. Kobie
Published 2019-03-01

Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vacc...

by Laura Rodriguez, Pilar Blanco-Lobo, Emma C. Reilly, Tatsuya Maehigashi, Aitor Nogales, Andrew Smith, David J. Topham, Stephen Dewhurst, Baek Kim, Luis Martínez-Sobrido
Published 2019-10-01

Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins.

by Amelia M Clark, Marta L DeDiego, Christopher S Anderson, Jiong Wang, Hongmei Yang, Aitor Nogales, Luis Martinez-Sobrido, Martin S Zand, Mark Y Sangster, David J Topham
Published 2017-01-01

Differences in Tissue and Species Tropism of Reptarenavirus Species Studied by Vesicular Stomatitis Virus Pseudotypes

by Yegor Korzyukov, Rommel Iheozor-Ejiofor, Lev Levanov, Teemu Smura, Udo Hetzel, Leonora Szirovicza, Juan Carlos de la Torre, Luis Martinez-Sobrido, Anja Kipar, Olli Vapalahti, Jussi Hepojoki
Published 2020-04-01

Structural basis of RNA cap modification by SARS-CoV-2

by Thiruselvam Viswanathan, Shailee Arya, Siu-Hong Chan, Shan Qi, Nan Dai, Anurag Misra, Jun-Gyu Park, Fatai Oladunni, Dmytro Kovalskyy, Robert A. Hromas, Luis Martinez-Sobrido, Yogesh K. Gupta
Published 2020-07-01

Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice.

by Jiong Wang, Shannon P Hilchey, Marta DeDiego, Sheldon Perry, Ollivier Hyrien, Aitor Nogales, Jessica Garigen, Fatima Amanat, Nelson Huertas, Florian Krammer, Luis Martinez-Sobrido, David J Topham, John J Treanor, Mark Y Sangster, Martin S Zand
Published 2018-01-01

A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region

by Yingyun Cai, Masaharu Iwasaki, Daisuke Motooka, David X. Liu, Shuiqing Yu, Kurt Cooper, Randy Hart, Ricky Adams, Tracey Burdette, Elena N. Postnikova, Jonathan Kurtz, Marisa St. Claire, Chengjin Ye, Jens H. Kuhn, Luis Martínez-Sobrido, Juan Carlos de la Torre
Published 2020-03-01

Functional Characterization and Direct Comparison of Influenza A, B, C, and D NS1 Proteins in vitro and in vivo

by Aitor Nogales, Aitor Nogales, Teresa Aydillo, Teresa Aydillo, Gines Ávila-Pérez, Alba Escalera, Kevin Chiem, Richard Cadagan, Richard Cadagan, Marta L. DeDiego, Feng Li, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Luis Martínez-Sobrido
Published 2019-12-01

A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene

by Yingyun Cai, Chengjin Ye, Benson Cheng, Aitor Nogales, Masaharu Iwasaki, Shuiqing Yu, Kurt Cooper, David X. Liu, Randy Hart, Ricky Adams, Tyler Brady, Elena N. Postnikova, Jonathan Kurtz, Marisa St Claire, Jens H. Kuhn, Juan Carlos de la Torre, Luis Martínez-Sobrido
Published 2020-02-01

Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2

by Kenneth S. Plante, Varun Dwivedi, Jessica A. Plante, Diana Fernandez, Divya Mirchandani, Nathen Bopp, Patricia V. Aguilar, Jun-Gyu Park, Paula Pino Tamayo, Jennifer Delgado, Vinay Shivanna, Jordi B. Torrelles, Luis Martinez-Sobrido, Rick Matos, Scott C. Weaver, K. Jagannadha Sastry, Robert A. Newman
Published 2021-06-01