SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

by Steffen Klein, Mirko Cortese, Sophie L. Winter, Moritz Wachsmuth-Melm, Christopher J. Neufeldt, Berati Cerikan, Megan L. Stanifer, Steeve Boulant, Ralf Bartenschlager, Petr Chlanda
Published 2020-11-01

Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle.

by Marco Binder, Nurgazy Sulaimanov, Diana Clausznitzer, Manuel Schulze, Christian M Hüber, Simon M Lenz, Johannes P Schlöder, Martin Trippler, Ralf Bartenschlager, Volker Lohmann, Lars Kaderali
Published 2013-01-01

RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection.

by Jae Seung Lee, Keisuke Tabata, Woan-Ing Twu, Md Shafiqur Rahman, Hee Sun Kim, Jin Bae Yu, Min Hyeok Jee, Ralf Bartenschlager, Sung Key Jang
Published 2019-09-01

Membrane alterations induced by nonstructural proteins of human norovirus.

by Sylvie Y Doerflinger, Mirko Cortese, Inés Romero-Brey, Zach Menne, Thibault Tubiana, Christian Schenk, Peter A White, Ralf Bartenschlager, Stéphane Bressanelli, Grant S Hansman, Volker Lohmann
Published 2017-10-01

Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production

by Mirko Cortese, Anil Kumar, Petr Matula, Lars Kaderali, Pietro Scaturro, Holger Erfle, Eliana Gisela Acosta, Sandra Buehler, Alessia Ruggieri, Laurent Chatel-Chaix, Karl Rohr, Ralf Bartenschlager
Published 2019-05-01

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

by Hanna Roth, Vera Magg, Fabian Uch, Pascal Mutz, Philipp Klein, Katharina Haneke, Volker Lohmann, Ralf Bartenschlager, Oliver T. Fackler, Nicolas Locker, Georg Stoecklin, Alessia Ruggieri, Michael J. Buchmeier
Published 2017-01-01

Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2'-O-Methylation Mutant.

by Bianca Schmid, Melanie Rinas, Alessia Ruggieri, Eliana Gisela Acosta, Marie Bartenschlager, Antje Reuter, Wolfgang Fischl, Nathalie Harder, Jan-Philip Bergeest, Michael Flossdorf, Karl Rohr, Thomas Höfer, Ralf Bartenschlager
Published 2015-12-01

Identification of HNRNPK as regulator of hepatitis C virus particle production.

by Marion Poenisch, Philippe Metz, Hagen Blankenburg, Alessia Ruggieri, Ji-Young Lee, Daniel Rupp, Ilka Rebhan, Kathrin Diederich, Lars Kaderali, Francisco S Domingues, Mario Albrecht, Volker Lohmann, Holger Erfle, Ralf Bartenschlager
Published 2015-01-01

A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach.

by Feng Yang, Jason M Robotham, Henry Grise, Stephen Frausto, Vanesa Madan, Margarita Zayas, Ralf Bartenschlager, Margaret Robinson, Andrew E Greenstein, Anita Nag, Timothy M Logan, Ewa Bienkiewicz, Hengli Tang
Published 2010-09-01

Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents.

by Prabhav Kalaghatgi, Anna Maria Sikorski, Elena Knops, Daniel Rupp, Saleta Sierra, Eva Heger, Maria Neumann-Fraune, Bastian Beggel, Andreas Walker, Jörg Timm, Hauke Walter, Martin Obermeier, Rolf Kaiser, Ralf Bartenschlager, Thomas Lengauer
Published 2016-01-01

Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication.

by Inés Romero-Brey, Andreas Merz, Abhilash Chiramel, Ji-Young Lee, Petr Chlanda, Uta Haselman, Rachel Santarella-Mellwig, Anja Habermann, Simone Hoppe, Stephanie Kallis, Paul Walther, Claude Antony, Jacomine Krijnse-Locker, Ralf Bartenschlager
Published 2012-01-01

From Multiplex Serology to Serolomics—A Novel Approach to the Antibody Response Against the SARS-CoV-2 Proteome

by Julia Butt, Rajagopal Murugan, Theresa Hippchen, Sylvia Olberg, Monique van Straaten, Hedda Wardemann, Erec Stebbins, Hans-Georg Kräusslich, Ralf Bartenschlager, Hermann Brenner, Vibor Laketa, Ben Schöttker, Barbara Müller, Uta Merle, Tim Waterboer
Published 2021-04-01

Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment

by Ji-Young Lee, Mirko Cortese, Uta Haselmann, Keisuke Tabata, Inés Romero-Brey, Charlotta Funaya, Nicole L. Schieber, Yu Qiang, Marie Bartenschlager, Stephanie Kallis, Christian Ritter, Karl Rohr, Yannick Schwab, Alessia Ruggieri, Ralf Bartenschlager
Published 2019-06-01

The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication.

by Benoît de Chassey, Anne Aublin-Gex, Alessia Ruggieri, Laurène Meyniel-Schicklin, Fabrine Pradezynski, Nathalie Davoust, Thibault Chantier, Lionel Tafforeau, Philippe-Emmanuel Mangeot, Claire Ciancia, Laure Perrin-Cocon, Ralf Bartenschlager, Patrice André, Vincent Lotteau
Published 2013-01-01

Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy.

by Julia Dietz, Daniel Rupp, Simone Susser, Johannes Vermehren, Kai-Henrik Peiffer, Natalie Filmann, Dimitra Bon, Thomas Kuntzen, Stefan Mauss, Georgios Grammatikos, Dany Perner, Caterina Berkowski, Eva Herrmann, Stefan Zeuzem, Ralf Bartenschlager, Christoph Sarrazin
Published 2016-01-01

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A.

by Lotte Coelmont, Xavier Hanoulle, Udayan Chatterji, Carola Berger, Joke Snoeck, Michael Bobardt, Precious Lim, Inge Vliegen, Jan Paeshuyse, Grégoire Vuagniaux, Anne-Mieke Vandamme, Anne-Mieke Vandamme, Ralf Bartenschlager, Philippe Gallay, Guy Lippens, Johan Neyts
Published 2010-10-01

Ultrastructural Characterization of Zika Virus Replication Factories

by Mirko Cortese, Sarah Goellner, Eliana Gisela Acosta, Christopher John Neufeldt, Olga Oleksiuk, Marko Lampe, Uta Haselmann, Charlotta Funaya, Nicole Schieber, Paolo Ronchi, Martin Schorb, Priit Pruunsild, Yannick Schwab, Laurent Chatel-Chaix, Alessia Ruggieri, Ralf Bartenschlager
Published 2017-02-01

Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin.

by Andrea Wuestenberg, Janine Kah, Katrin Singethan, Hüseyin Sirma, Amelie Dorothea Keller, Sergio René Perez Rosal, Jörg Schrader, Christine Loscher, Tassilo Volz, Ralf Bartenschlager, Volker Lohmann, Ulrike Protzer, Maura Dandri, Ansgar W Lohse, Gisa Tiegs, Gabriele Sass
Published 2014-01-01

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses.

by Katharina Robichon, Tim Maiwald, Marcel Schilling, Annette Schneider, Joschka Willemsen, Florian Salopiata, Melissa Teusel, Clemens Kreutz, Christian Ehlting, Jun Huang, Sajib Chakraborty, Xiaoyun Huang, Georg Damm, Daniel Seehofer, Philipp A Lang, Johannes G Bode, Marco Binder, Ralf Bartenschlager, Jens Timmer, Ursula Klingmüller
Published 2020-10-01

SARS‐CoV‐2 infection remodels the host protein thermal stability landscape

by Joel Selkrig, Megan Stanifer, André Mateus, Karin Mitosch, Inigo Barrio‐Hernandez, Mandy Rettel, Heeyoung Kim, Carlos G P Voogdt, Philipp Walch, Carmon Kee, Nils Kurzawa, Frank Stein, Clément Potel, Anna Jarzab, Bernhard Kuster, Ralf Bartenschlager, Steeve Boulant, Pedro Beltrao, Athanasios Typas, Mikhail M Savitski
Published 2021-02-01