The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma

by Lennart Lenk, Maren Pein, Olga Will, Beatriz Gomez, Fabrice Viol, Charlotte Hauser, Jan-Hendrik Egberts, Jan-Paul Gundlach, Ole Helm, Sanjay Tiwari, Ralf Weiskirchen, Stefan Rose-John, Christoph Röcken, Wolfgang Mikulits, Patrick Wenzel, Günter Schneider, Dieter Saur, Heiner Schäfer, Susanne Sebens
Published 2018-01-01

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

by Marco Heestermans, Clément Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A. Friese, Mathias Gelderblom, Albert Sickmann, Roger J. S. Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M. Butler, Ophira Salomon, Evi X. Stavrou, Thomas Renné
Published 2021-09-01

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

by Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek, Philipp Arnold, Katharina Knittler, Frederike Wilkens, Barbara Potempa, Björn Rabe, Marit Stirnberg, Ralph Lucius, Jörg W. Bartsch, Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John, Jan Potempa, Gunnar C. Hansson, Peter J. Dempsey, Christoph Becker-Pauly
Published 2017-11-01

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

by Steffen Riethmueller, Prasath Somasundaram, Johanna C Ehlers, Chien-Wen Hung, Charlotte M Flynn, Juliane Lokau, Maria Agthe, Stefan Düsterhöft, Yijue Zhu, Joachim Grötzinger, Inken Lorenzen, Tomas Koudelka, Kosuke Yamamoto, Ute Pickhinke, Rielana Wichert, Christoph Becker-Pauly, Marisa Rädisch, Alexander Albrecht, Markus Hessefort, Dominik Stahnke, Carlo Unverzagt, Stefan Rose-John, Andreas Tholey, Christoph Garbers
Published 2017-01-01

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

by Mohamed I Saad, Sultan Alhayyani, Louise McLeod, Liang Yu, Mohammad Alanazi, Virginie Deswaerte, Ke Tang, Thierry Jarde, Julian A Smith, Zdenka Prodanovic, Michelle D Tate, Jesse J Balic, D Neil Watkins, Jason E Cain, Steven Bozinovski, Elizabeth Algar, Tomohiro Kohmoto, Hiromichi Ebi, Walter Ferlin, Christoph Garbers, Saleela Ruwanpura, Irit Sagi, Stefan Rose‐John, Brendan J Jenkins
Published 2019-04-01

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency

by Melanie Werner-Klein, Ana Grujovic, Christoph Irlbeck, Milan Obradović, Martin Hoffmann, Huiqin Koerkel-Qu, Xin Lu, Steffi Treitschke, Cäcilia Köstler, Catherine Botteron, Kathrin Weidele, Christian Werno, Bernhard Polzer, Stefan Kirsch, Miodrag Gužvić, Jens Warfsmann, Kamran Honarnejad, Zbigniew Czyz, Giancarlo Feliciello, Isabell Blochberger, Sandra Grunewald, Elisabeth Schneider, Gundula Haunschild, Nina Patwary, Severin Guetter, Sandra Huber, Brigitte Rack, Nadia Harbeck, Stefan Buchholz, Petra Rümmele, Norbert Heine, Stefan Rose-John, Christoph A. Klein
Published 2020-10-01

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib

by Svantje Sobotta, Andreas Raue, Xiaoyun Huang, Joep Vanlier, Joep Vanlier, Anja Jünger, Sebastian Bohl, Ute Albrecht, Maximilian J. Hahnel, Stephanie Wolf, Nikola S. Mueller, Lorenza A. D'Alessandro, Stephanie Mueller-Bohl, Martin E. Boehm, Philippe Lucarelli, Sandra Bonefas, Georg Damm, Daniel Seehofer, Wolf D. Lehmann, Stefan Rose-John, Frank van der Hoeven, Norbert Gretz, Fabian J. Theis, Fabian J. Theis, Christian Ehlting, Johannes G. Bode, Jens Timmer, Jens Timmer, Marcel Schilling, Ursula Klingmüller
Published 2017-10-01

An evaluation of land degradation and desertification in the Jeffara Plain, Libya

by Mnsur, Shaban Emhamed Abdsmad
Published 2014

The evaluation of woodland status by means of botanical indicator species

by Vickers, Adrian David
Published 2001