Enhancer-associated H3K4 methylation safeguards in vitro germline competence

by Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik, Álvaro Rada-Iglesias
Published 2021-10-01

Differentially Methylated Regions in Desmoid-Type Fibromatosis: A Comparison Between CTNNB1 S45F and T41A Tumors

by Milea J. M. Timbergen, Milea J. M. Timbergen, Ruben Boers, Anne L. M. Vriends, Joachim Boers, Wilfred F. J. van IJcken, Marla Lavrijsen, Dirk J. Grünhagen, Cornelis Verhoef, Stefan Sleijfer, Ron Smits, Joost Gribnau, Erik A. C. Wiemer
Published 2020-10-01

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease

by Sara Sepe, Chiara Milanese, Sylvia Gabriels, Kasper W.J. Derks, Cesar Payan-Gomez, Wilfred F.J. van IJcken, Yvonne M.A. Rijksen, Alex L. Nigg, Sandra Moreno, Silvia Cerri, Fabio Blandini, Jan H.J. Hoeijmakers, Pier G. Mastroberardino
Published 2016-05-01

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

by Corine M Beaufort, Jean C A Helmijr, Anna M Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F J van IJcken, Anouk A J Heine, Marcel Smid, Marco J Koudijs, James D Brenton, Els M J J Berns, Jozien Helleman
Published 2014-01-01

Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation

by Bobby W. S. Li, Ralph Stadhouders, Marjolein J. W. de Bruijn, Melanie Lukkes, Dior M. J. M. Beerens, Maarten D. Brem, Alex KleinJan, Ingrid Bergen, Heleen Vroman, Mirjam Kool, Wilfred F. J. van IJcken, Tata Nageswara Rao, Hans Jörg Fehling, Rudi W. Hendriks
Published 2017-12-01

MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma.

by Melissa Vos, Ruben Boers, Anne L M Vriends, Joachim Boers, Patricia F van Kuijk, Winan J van Houdt, Geert J L H van Leenders, Michal Wagrodzki, Wilfred F J van IJcken, Joost Gribnau, Dirk J Grünhagen, Cornelis Verhoef, Stefan Sleijfer, Erik A C Wiemer
Published 2020-01-01

Histological, immunohistochemical and transcriptomic characterization of human tracheoesophageal fistulas.

by Erwin Brosens, Janine F Felix, Anne Boerema-de Munck, Elisabeth M de Jong, Elisabeth M Lodder, Sigrid Swagemakers, Marjon Buscop-van Kempen, Ronald R de Krijger, Rene M H Wijnen, Wilfred F J van IJcken, Peter van der Spek, Annelies de Klein, Dick Tibboel, Robbert J Rottier
Published 2020-01-01

Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation.

by Manzhi Zhao, Caoimhe H Kiernan, Christopher J Stairiker, Jennifer L Hope, Leticia G Leon, Marjan van Meurs, Inge Brouwers-Haspels, Ruben Boers, Joachim Boers, Joost Gribnau, Wilfred F J van IJcken, Eric M Bindels, Remco M Hoogenboezem, Stefan J Erkeland, Yvonne M Mueller, Peter D Katsikis
Published 2020-06-01

Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness

by Dina Vojinovic, Maryam Kavousi, Mohsen Ghanbari, Mohsen Ghanbari, Rutger W. W. Brouwer, Jeroen G. J. van Rooij, Mirjam C. G. N. van den Hout, Robert Kraaij, Wilfred F. J. van Ijcken, Andre G. Uitterlinden, Andre G. Uitterlinden, Cornelia M. van Duijn, Cornelia M. van Duijn, Najaf Amin
Published 2018-10-01

Transcriptomic Analyses Reveal Differential Gene Expression of Immune and Cell Death Pathways in the Brains of Mice Infected with West Nile Virus and Chikungunya Virus

by Stephanie M. Lim, Henk-Jan van den Ham, Minoushka Oduber, Eurydice Martina, Fatiha Zaaraoui-Boutahar, Jeroen M. Roose, Wilfred F. J. van IJcken, Albert D. M. E. Osterhaus, Albert D. M. E. Osterhaus, Arno C. Andeweg, Penelope Koraka, Byron E. E. Martina, Byron E. E. Martina
Published 2017-08-01

Time since onset of disease and individual clinical markers associate with transcriptional changes in uncomplicated dengue.

by Cornelia A M van de Weg, Henk-Jan van den Ham, Maarten A Bijl, Fatih Anfasa, Fatiha Zaaraoui-Boutahar, Beti E Dewi, Leonard Nainggolan, Wilfred F J van IJcken, Albert D M E Osterhaus, Byron E E Martina, Eric C M van Gorp, Arno C Andeweg
Published 2015-03-01

Alveolar barrier disruption in varicella pneumonia is associated with neutrophil extracellular trap formation

by Werner J.D. Ouwendijk, Henk-Jan van den Ham, Mark W. Delany, Jeroen J.A. van Kampen, Gijsbert P. van Nierop, Tamana Mehraban, Fatiha Zaaraoui-Boutahar, Wilfred F.J. van IJcken, Judith M.A. van den Brand, Rory D. de Vries, Arno C. Andeweg, Georges M.G.M. Verjans
Published 2020-11-01

MAU2 and NIPBL Variants Impair the Heterodimerization of the Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome

by Ilaria Parenti, Farah Diab, Sara Ruiz Gil, Eskeatnaf Mulugeta, Valentina Casa, Riccardo Berutti, Rutger W.W. Brouwer, Valerie Dupé, Juliane Eckhold, Elisabeth Graf, Beatriz Puisac, Feliciano Ramos, Thomas Schwarzmayr, Macarena Moronta Gines, Thomas van Staveren, Wilfred F.J. van IJcken, Tim M. Strom, Juan Pié, Erwan Watrin, Frank J. Kaiser, Kerstin S. Wendt
Published 2020-05-01

DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells

by Adone Mohd-Sarip, Miriam Teeuwssen, Alice G. Bot, Maria J. De Herdt, Stefan M. Willems, Robert J. Baatenburg de Jong, Leendert H.J. Looijenga, Diana Zatreanu, Karel Bezstarosti, Job van Riet, Edwin Oole, Wilfred F.J. van Ijcken, Harmen J.G. van de Werken, Jeroen A. Demmers, Riccardo Fodde, C. Peter Verrijzer
Published 2017-07-01

Cystic renal‐epithelial derived induced pluripotent stem cells from polycystic kidney disease patients

by Annegien T. Kenter, Eveline Rentmeester, Job vanRiet, Ruben Boers, Joachim Boers, Mehrnaz Ghazvini, Vanessa J. Xavier, Geert J.L.H. vanLeenders, Paul C.M.S. Verhagen, Marjan E. vanTil, Bert Eussen, Monique Losekoot, Annelies deKlein, Dorien J.M. Peters, Wilfred F.J. vanIJcken, Harmen J.G. van deWerken, Robert Zietse, Ewout J. Hoorn, Gert Jansen, Joost H. Gribnau
Published 2020-04-01

Circulating mutations are associated with early tumor progression and poor survival in pancreatic cancer patients treated with FOLFIRINOX

by Fleur van der Sijde, Zakia Azmani, Marc G. Besselink, Bert A. Bonsing, Jan Willem B. de Groot, Bas Groot Koerkamp, Brigitte C. M. Haberkorn, Marjolein Y. V. Homs, Wilfred F. J. van IJcken, Quisette P. Janssen, Martijn P. Lolkema, Saskia A. C. Luelmo, Leonie J. M. Mekenkamp, Dana A. M. Mustafa, Ron H. N. van Schaik, Johanna W. Wilmink, Eveline E. Vietsch, Casper H. J. van Eijck
Published 2021-08-01

Exome Sequencing Analysis Identifies Rare Variants in ATM and RPL8 That Are Associated With Shorter Telomere Length

by Ashley van der Spek, Ashley van der Spek, Sophie C. Warner, Linda Broer, Christopher P. Nelson, Christopher P. Nelson, Dina Vojinovic, Shahzad Ahmad, Pascal P. Arp, Rutger W. W. Brouwer, Matthew Denniff, Mirjam C. G. N. van den Hout, Jeroen G. J. van Rooij, Jeroen G. J. van Rooij, Robert Kraaij, Wilfred F. J. van IJcken, Nilesh J. Samani, Nilesh J. Samani, M. Arfan Ikram, André G. Uitterlinden, André G. Uitterlinden, Veryan Codd, Veryan Codd, Najaf Amin, Najaf Amin, Cornelia M. van Duijn, Cornelia M. van Duijn
Published 2020-04-01

Exome-Wide Meta-Analysis Identifies Rare 3′-UTR Variant in ERCC1/CD3EAP Associated with Symptoms of Sleep Apnea

by Ashley van der Spek, Annemarie I. Luik, Desana Kocevska, Chunyu Liu, Chunyu Liu, Chunyu Liu, Rutger W. W. Brouwer, Jeroen G. J. van Rooij, Jeroen G. J. van Rooij, Jeroen G. J. van Rooij, Mirjam C. G. N. van den Hout, Robert Kraaij, Robert Kraaij, Robert Kraaij, Albert Hofman, Albert Hofman, André G. Uitterlinden, André G. Uitterlinden, André G. Uitterlinden, Wilfred F. J. van IJcken, Daniel J. Gottlieb, Daniel J. Gottlieb, Daniel J. Gottlieb, Henning Tiemeier, Henning Tiemeier, Cornelia M. van Duijn, Najaf Amin
Published 2017-10-01