Article human Architecture Bioluminescence activated Photodynamic Therapy Cell Membrane Customer benefits Customer characteristics DREAM challenge Engagement Gamification Grade 4 astrocytoma cells Humans Hypericin Landscape art & architecture Medication Adherence Medication Therapy Management Molecular Biology Patient Selection Primary Health Care Protein Biochemistry Protein expression and purification RNA RNA analysis RNA binding protein RNA extraction RNA isolation RNA sequence RNA sequencing RNA-seq Retrospective Studies