A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance

In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to redu...

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Main Authors:	Brandon A Howard, Olga G James, Jennifer M Perkins, Robert A Pagnanelli, Salvador Borges-Neto, Robert E Reiman
Format:	Article
Language:	English
Published:	SAGE Publishing 2017-12-01
Series:	SAGE Open Medical Case Reports
Online Access:	https://doi.org/10.1177/2050313X17745203

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spelling	doaj-000205d7943c4d4db1bfaf1b6aff31282020-11-25T02:34:09ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2017-12-01510.1177/2050313X17745203A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearanceBrandon A Howard0Olga G James1Jennifer M Perkins2Robert A Pagnanelli3Salvador Borges-Neto4Robert E Reiman5Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, NC, USADivision of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, NC, USADivision of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USADivision of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, NC, USADivision of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, NC, USADivision of Radiation Safety, Occupational and Environmental Safety Office, Duke University, Durham, NC, USAIn thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration.https://doi.org/10.1177/2050313X17745203
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Brandon A Howard Olga G James Jennifer M Perkins Robert A Pagnanelli Salvador Borges-Neto Robert E Reiman
spellingShingle	Brandon A Howard Olga G James Jennifer M Perkins Robert A Pagnanelli Salvador Borges-Neto Robert E Reiman A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance SAGE Open Medical Case Reports
author_facet	Brandon A Howard Olga G James Jennifer M Perkins Robert A Pagnanelli Salvador Borges-Neto Robert E Reiman
author_sort	Brandon A Howard
title	A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_short	A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_full	A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_fullStr	A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_full_unstemmed	A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
title_sort	practical method of i-131 thyroid cancer therapy dose optimization using estimated effective renal clearance
publisher	SAGE Publishing
series	SAGE Open Medical Case Reports
issn	2050-313X
publishDate	2017-12-01
description	In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration.
url	https://doi.org/10.1177/2050313X17745203
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A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance

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