Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease
For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodromal phases of the disease, when treatment is thought...
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doaj-0003ce4bbc2641999a3bd8d9197955712020-11-24T21:49:12ZengMDPI AGMetabolites2218-19892018-10-01847110.3390/metabo8040071metabo8040071Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s DiseaseStewart F. Graham0Nolwen L. Rey1Zafer Ugur2Ali Yilmaz3Eric Sherman4Michael Maddens5Ray O. Bahado-Singh6Katelyn Becker7Emily Schulz8Lindsay K. Meyerdirk9Jennifer A. Steiner10Jiyan Ma11Patrik Brundin12Beaumont Health, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USACenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USABeaumont Health, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USABeaumont Health, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USAUniversity of Michigan, Ann Arbor, MI 48109, USABeaumont Health, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USABeaumont Health, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USACenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USACenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USACenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USACenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USACenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USACenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USAFor people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodromal phases of the disease, when treatment is thought to be most effective. Currently, there are no robust biomarkers that aid in the early diagnosis of PD. Following previously reported work by our group, we accurately measured the concentrations of 18 bile acids in the serum of a prodromal mouse model of PD. We identified three bile acids at significantly different concentrations (<i>p</i> < 0.05) when mice representing a prodromal PD model were compared with controls. These include ω-murichoclic acid (MCAo), tauroursodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA). All were down-regulated in prodromal PD mice with TUDCA and UDCA at significantly lower levels (17-fold and 14-fold decrease, respectively). Using the concentration of three bile acids combined with logistic regression, we can discriminate between prodromal PD mice from control mice with high accuracy (AUC (95% CI) = 0.906 (0.777⁻1.000)) following cross validation. Our study highlights the need to investigate bile acids as potential biomarkers that predict PD and possibly reflect the progression of manifest PD.https://www.mdpi.com/2218-1989/8/4/71prodromal Parkinson’s diseasebile acidsmass spectrometrybiomarkersα-synuclein aggregates |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stewart F. Graham Nolwen L. Rey Zafer Ugur Ali Yilmaz Eric Sherman Michael Maddens Ray O. Bahado-Singh Katelyn Becker Emily Schulz Lindsay K. Meyerdirk Jennifer A. Steiner Jiyan Ma Patrik Brundin |
spellingShingle |
Stewart F. Graham Nolwen L. Rey Zafer Ugur Ali Yilmaz Eric Sherman Michael Maddens Ray O. Bahado-Singh Katelyn Becker Emily Schulz Lindsay K. Meyerdirk Jennifer A. Steiner Jiyan Ma Patrik Brundin Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease Metabolites prodromal Parkinson’s disease bile acids mass spectrometry biomarkers α-synuclein aggregates |
author_facet |
Stewart F. Graham Nolwen L. Rey Zafer Ugur Ali Yilmaz Eric Sherman Michael Maddens Ray O. Bahado-Singh Katelyn Becker Emily Schulz Lindsay K. Meyerdirk Jennifer A. Steiner Jiyan Ma Patrik Brundin |
author_sort |
Stewart F. Graham |
title |
Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease |
title_short |
Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease |
title_full |
Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease |
title_fullStr |
Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease |
title_full_unstemmed |
Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease |
title_sort |
metabolomic profiling of bile acids in an experimental model of prodromal parkinson’s disease |
publisher |
MDPI AG |
series |
Metabolites |
issn |
2218-1989 |
publishDate |
2018-10-01 |
description |
For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodromal phases of the disease, when treatment is thought to be most effective. Currently, there are no robust biomarkers that aid in the early diagnosis of PD. Following previously reported work by our group, we accurately measured the concentrations of 18 bile acids in the serum of a prodromal mouse model of PD. We identified three bile acids at significantly different concentrations (<i>p</i> < 0.05) when mice representing a prodromal PD model were compared with controls. These include ω-murichoclic acid (MCAo), tauroursodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA). All were down-regulated in prodromal PD mice with TUDCA and UDCA at significantly lower levels (17-fold and 14-fold decrease, respectively). Using the concentration of three bile acids combined with logistic regression, we can discriminate between prodromal PD mice from control mice with high accuracy (AUC (95% CI) = 0.906 (0.777⁻1.000)) following cross validation. Our study highlights the need to investigate bile acids as potential biomarkers that predict PD and possibly reflect the progression of manifest PD. |
topic |
prodromal Parkinson’s disease bile acids mass spectrometry biomarkers α-synuclein aggregates |
url |
https://www.mdpi.com/2218-1989/8/4/71 |
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