RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

Therapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contribut...

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Main Authors: Xinzhou Zhu, Jingyi Yan, Catherine Bregere, Andrea Zelmer, Tessa Goerne, Josef P. Kapfhammer, Raphael Guzman, Sven Wellmann
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11870-x
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spelling doaj-00099bf8d81d43ab991574c74cdbdc992021-05-11T12:02:27ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-11870-xRBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injuryXinzhou Zhu0Jingyi Yan1Catherine Bregere2Andrea Zelmer3Tessa Goerne4Josef P. Kapfhammer5Raphael Guzman6Sven Wellmann7University Children’s Hospital Basel (UKBB), University of BaselUniversity Children’s Hospital Basel (UKBB), University of BaselDepartment of Biomedicine, University of BaselUniversity Children’s Hospital Basel (UKBB), University of BaselUniversity Children’s Hospital Basel (UKBB), University of BaselDepartment of Biomedicine, University of BaselDepartment of Biomedicine, University of BaselUniversity Children’s Hospital Basel (UKBB), University of BaselTherapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contributes substantially to neuroregeneration after adult HI injury, specifically in the subventricular zone and subgranular zone.https://doi.org/10.1038/s41467-019-11870-x
collection DOAJ
language English
format Article
sources DOAJ
author Xinzhou Zhu
Jingyi Yan
Catherine Bregere
Andrea Zelmer
Tessa Goerne
Josef P. Kapfhammer
Raphael Guzman
Sven Wellmann
spellingShingle Xinzhou Zhu
Jingyi Yan
Catherine Bregere
Andrea Zelmer
Tessa Goerne
Josef P. Kapfhammer
Raphael Guzman
Sven Wellmann
RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
Nature Communications
author_facet Xinzhou Zhu
Jingyi Yan
Catherine Bregere
Andrea Zelmer
Tessa Goerne
Josef P. Kapfhammer
Raphael Guzman
Sven Wellmann
author_sort Xinzhou Zhu
title RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_short RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_full RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_fullStr RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_full_unstemmed RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
title_sort rbm3 promotes neurogenesis in a niche-dependent manner via imp2-igf2 signaling pathway after hypoxic-ischemic brain injury
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description Therapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contributes substantially to neuroregeneration after adult HI injury, specifically in the subventricular zone and subgranular zone.
url https://doi.org/10.1038/s41467-019-11870-x
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AT jingyiyan rbm3promotesneurogenesisinanichedependentmannerviaimp2igf2signalingpathwayafterhypoxicischemicbraininjury
AT catherinebregere rbm3promotesneurogenesisinanichedependentmannerviaimp2igf2signalingpathwayafterhypoxicischemicbraininjury
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