RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
Therapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contribut...
Main Authors: | Xinzhou Zhu, Jingyi Yan, Catherine Bregere, Andrea Zelmer, Tessa Goerne, Josef P. Kapfhammer, Raphael Guzman, Sven Wellmann |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-09-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11870-x |
Similar Items
-
The RNA-Binding Protein RBM3 Promotes Neural Stem Cell (NSC) Proliferation Under Hypoxia
by: Jingyi Yan, et al.
Published: (2019-11-01) -
The RNA-binding protein RBM3 is involved in hypothermia induced neuroprotection
by: Sophorn Chip, et al.
Published: (2011-08-01) -
mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry
by: Dai, Ning, et al.
Published: (2014) -
IGF2BP3 (IMP3) expression in angiosarcoma, epithelioid hemangioendothelioma, and benign vascular lesions
by: Misuzu Okabayshi, et al.
Published: (2020-03-01) -
RNA‐Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation
by: Hong‐Bin Liu, et al.
Published: (2019-08-01)