Neural Stem Cell Transplantation for Neurodegenerative Diseases
Neurodegenerative diseases are disabling and fatal neurological disorders that currently lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a potential therapeutic approach and appears to exert a beneficial effect against neurodegeneration via different mechanisms,...
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doaj-00130061a9c74123829d7bcfacb4695f2020-11-25T03:06:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01213103310310.3390/ijms21093103Neural Stem Cell Transplantation for Neurodegenerative DiseasesRoberta De Gioia0Fabio Biella1Gaia Citterio2Federica Rizzo3Elena Abati4Monica Nizzardo5Nereo Bresolin6Giacomo Pietro Comi7Stefania Corti8Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurology Unit, Via Francesco Sforza 35, 20122 Milan, ItalyDino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, 20122 Milan, ItalyDino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, 20122 Milan, ItalyFoundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurology Unit, Via Francesco Sforza 35, 20122 Milan, ItalyDino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, 20122 Milan, ItalyFoundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurology Unit, Via Francesco Sforza 35, 20122 Milan, ItalyFoundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurology Unit, Via Francesco Sforza 35, 20122 Milan, ItalyDino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, 20122 Milan, ItalyFoundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurology Unit, Via Francesco Sforza 35, 20122 Milan, ItalyNeurodegenerative diseases are disabling and fatal neurological disorders that currently lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a potential therapeutic approach and appears to exert a beneficial effect against neurodegeneration via different mechanisms, such as the production of neurotrophic factors, decreased neuroinflammation, enhanced neuronal plasticity and cell replacement. Thus, NSC transplantation may represent an effective therapeutic strategy. To exploit NSCs’ potential, some of their essential biological characteristics must be thoroughly investigated, including the specific markers for NSC subpopulations, to allow profiling and selection. Another key feature is their secretome, which is responsible for the regulation of intercellular communication, neuroprotection, and immunomodulation. In addition, NSCs must properly migrate into the central nervous system (CNS) and integrate into host neuronal circuits, enhancing neuroplasticity. Understanding and modulating these aspects can allow us to further exploit the therapeutic potential of NSCs. Recent progress in gene editing and cellular engineering techniques has opened up the possibility of modifying NSCs to express select candidate molecules to further enhance their therapeutic effects. This review summarizes current knowledge regarding these aspects, promoting the development of stem cell therapies that could be applied safely and effectively in clinical settings.https://www.mdpi.com/1422-0067/21/9/3103neuronal stem cellsneural subpopulationneurodegenerative diseasecell therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roberta De Gioia Fabio Biella Gaia Citterio Federica Rizzo Elena Abati Monica Nizzardo Nereo Bresolin Giacomo Pietro Comi Stefania Corti |
spellingShingle |
Roberta De Gioia Fabio Biella Gaia Citterio Federica Rizzo Elena Abati Monica Nizzardo Nereo Bresolin Giacomo Pietro Comi Stefania Corti Neural Stem Cell Transplantation for Neurodegenerative Diseases International Journal of Molecular Sciences neuronal stem cells neural subpopulation neurodegenerative disease cell therapy |
author_facet |
Roberta De Gioia Fabio Biella Gaia Citterio Federica Rizzo Elena Abati Monica Nizzardo Nereo Bresolin Giacomo Pietro Comi Stefania Corti |
author_sort |
Roberta De Gioia |
title |
Neural Stem Cell Transplantation for Neurodegenerative Diseases |
title_short |
Neural Stem Cell Transplantation for Neurodegenerative Diseases |
title_full |
Neural Stem Cell Transplantation for Neurodegenerative Diseases |
title_fullStr |
Neural Stem Cell Transplantation for Neurodegenerative Diseases |
title_full_unstemmed |
Neural Stem Cell Transplantation for Neurodegenerative Diseases |
title_sort |
neural stem cell transplantation for neurodegenerative diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-04-01 |
description |
Neurodegenerative diseases are disabling and fatal neurological disorders that currently lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a potential therapeutic approach and appears to exert a beneficial effect against neurodegeneration via different mechanisms, such as the production of neurotrophic factors, decreased neuroinflammation, enhanced neuronal plasticity and cell replacement. Thus, NSC transplantation may represent an effective therapeutic strategy. To exploit NSCs’ potential, some of their essential biological characteristics must be thoroughly investigated, including the specific markers for NSC subpopulations, to allow profiling and selection. Another key feature is their secretome, which is responsible for the regulation of intercellular communication, neuroprotection, and immunomodulation. In addition, NSCs must properly migrate into the central nervous system (CNS) and integrate into host neuronal circuits, enhancing neuroplasticity. Understanding and modulating these aspects can allow us to further exploit the therapeutic potential of NSCs. Recent progress in gene editing and cellular engineering techniques has opened up the possibility of modifying NSCs to express select candidate molecules to further enhance their therapeutic effects. This review summarizes current knowledge regarding these aspects, promoting the development of stem cell therapies that could be applied safely and effectively in clinical settings. |
topic |
neuronal stem cells neural subpopulation neurodegenerative disease cell therapy |
url |
https://www.mdpi.com/1422-0067/21/9/3103 |
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