POSSIBILITIES OF REGENERATION OF THE MUSCLES OF THE SOFT PALATE DURING ITS NONUNION DEPENDING ON THE MYOGENIC POTENTIAL OF STEM CELLS. Review

• Main Authors: L.V. Kharkov, R.I. Egorov
• Format: Article
• Language: English
• Published: Bogomolets National Medical University 2020-09-01
• Series: Медична наука України
• Subjects: nonunion of the upper lip and palate, muscle injury, satellite stem cells, engraftment, myofibrils, marker
• Online Access: https://msu-journal.com/index.php/journal/article/view/233

Relevance. Today there are more than 150 methods for eliminating congenital defects of the hard and soft palate. However, these techniques do not always lead to high functional results, which leads to repeated surgical interventions and long-term speech therapy rehabilitation. Therefore, there is a problem with the prognosis of such treatment. The search for a marker for assessing the prognosis of surgical intervention is relevant. One of these markers may be the state of the myogenic potential of stem cells. Objective: to analyze the possibility of preliminary assessment of muscle regeneration, depending on the myogenic potential of stem cells, in order to increase the effectiveness of treatment of children with non-union of the soft palate. Method. An analytical review of the literature on keywords from the scientometric databases PubMed, Scopus, Web of Science. Results. Satellite cells represent an adequate system model for studying the biology of adult stem cells. Satellite cells can be considered candidates for cell therapy in muscle regeneration. First, they are one of the most abundant and most accessible cells in our body. Secondly, there is a panel of specific markers that can be used to isolate satellite cells. Third, satellite cells are localized within clear boundaries of the anatomical niche, and signaling mechanisms are currently being studied. Fourth, there is the possibility of recreating muscle injuries in which satellite cells can be studied. Future research aimed at increasing the purification of satellite cells so as to maintain their low differentiation, increase the engraftment potential, as well as new approaches aimed at obtaining satellite cells from iPS cells, will help accelerate the progress and development of drugs for cell therapy in the treatment of muscle degenerative diseases. Conclusions. The data on the myogenic potential of stem cells, in muscle regeneration, obtained on satellite cell models, can be used to increase the effectiveness of the treatment of children with nonunion of the soft palate.