Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield.
Microbes may maximize the number of daughter cells per time or per amount of nutrients consumed. These two strategies correspond, respectively, to the use of enzyme-efficient or substrate-efficient metabolic pathways. In reality, fast growth is often associated with wasteful, yield-inefficient metab...
Main Authors: | Meike T Wortel, Elad Noor, Michael Ferris, Frank J Bruggeman, Wolfram Liebermeister |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-02-01
|
Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC5847312?pdf=render |
Similar Items
-
The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization.
by: Elad Noor, et al.
Published: (2016-11-01) -
Functional Trade-Offs in Promiscuous Enzymes Cannot Be Explained by Intrinsic Mutational Robustness of the Native Activity.
by: Miriam Kaltenbach, et al.
Published: (2016-10-01) -
Trade-offs of predation and foraging explain sexual segregation in African buffalo
by: Hay, CT, et al.
Published: (2008) -
Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load.
by: Naama Tepper, et al.
Published: (2013-01-01) -
Modeling microbial metabolic trade-offs in a chemostat.
by: Zhiyuan Li, et al.
Published: (2020-08-01)