A Review of Fungal Protoilludane Sesquiterpenoid Natural Products

A Review of Fungal Protoilludane Sesquiterpenoid Natural Products

Natural products have been a great source for drug leads, due to a vast majority possessing unique chemical structures. Such an example is the protoilludane class of natural products which contain an annulated 5/6/4-ring system and are almost exclusively produced by fungi. They have been reported to...

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Bibliographic Details
Main Authors: Melissa M. Cadelis, Brent R. Copp, Siouxsie Wiles
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Antibiotics
Subjects:
sesquiterpenoid
natural products
protoilludanes
Online Access:https://www.mdpi.com/2079-6382/9/12/928
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spelling doaj-002f66b4950f4edba088e20d0ee227ae2020-12-20T00:01:43ZengMDPI AGAntibiotics2079-63822020-12-01992892810.3390/antibiotics9120928A Review of Fungal Protoilludane Sesquiterpenoid Natural ProductsMelissa M. Cadelis0Brent R. Copp1Siouxsie Wiles2School of Chemical Sciences, University of Auckland, 23 Symonds Street, 1010 Auckland, New ZealandSchool of Chemical Sciences, University of Auckland, 23 Symonds Street, 1010 Auckland, New ZealandBioluminescent Superbugs Lab, School of Medical Sciences, University of Auckland, 85 Park Road, Grafton, 1023 Auckland, New ZealandNatural products have been a great source for drug leads, due to a vast majority possessing unique chemical structures. Such an example is the protoilludane class of natural products which contain an annulated 5/6/4-ring system and are almost exclusively produced by fungi. They have been reported to possess a diverse range of bioactivities, including antimicrobial, antifungal and cytotoxic properties. In this review, we discuss the isolation, structure elucidation and any reported bioactivities of this compound class, including establishment of stereochemistry and any total syntheses of these natural products. A total of 180 protoilludane natural products, isolated in the last 70 years, from fungi, plant and marine sources are covered, highlighting their structural diversity and potential in drug discovery.https://www.mdpi.com/2079-6382/9/12/928sesquiterpenoidnatural productsprotoilludanes
collection DOAJ
language English
format Article
sources DOAJ
author Melissa M. Cadelis
Brent R. Copp
Siouxsie Wiles
spellingShingle Melissa M. Cadelis
Brent R. Copp
Siouxsie Wiles
A Review of Fungal Protoilludane Sesquiterpenoid Natural Products
Antibiotics
sesquiterpenoid
natural products
protoilludanes
author_facet Melissa M. Cadelis
Brent R. Copp
Siouxsie Wiles
author_sort Melissa M. Cadelis
title A Review of Fungal Protoilludane Sesquiterpenoid Natural Products
title_short A Review of Fungal Protoilludane Sesquiterpenoid Natural Products
title_full A Review of Fungal Protoilludane Sesquiterpenoid Natural Products
title_fullStr A Review of Fungal Protoilludane Sesquiterpenoid Natural Products
title_full_unstemmed A Review of Fungal Protoilludane Sesquiterpenoid Natural Products
title_sort review of fungal protoilludane sesquiterpenoid natural products
publisher MDPI AG
series Antibiotics
issn 2079-6382
publishDate 2020-12-01
description Natural products have been a great source for drug leads, due to a vast majority possessing unique chemical structures. Such an example is the protoilludane class of natural products which contain an annulated 5/6/4-ring system and are almost exclusively produced by fungi. They have been reported to possess a diverse range of bioactivities, including antimicrobial, antifungal and cytotoxic properties. In this review, we discuss the isolation, structure elucidation and any reported bioactivities of this compound class, including establishment of stereochemistry and any total syntheses of these natural products. A total of 180 protoilludane natural products, isolated in the last 70 years, from fungi, plant and marine sources are covered, highlighting their structural diversity and potential in drug discovery.
topic sesquiterpenoid
natural products
protoilludanes
url https://www.mdpi.com/2079-6382/9/12/928
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