The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.
Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide li...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC3386237?pdf=render |
id |
doaj-00349c928f224e4c83d88e5a63ee02a6 |
---|---|
record_format |
Article |
spelling |
doaj-00349c928f224e4c83d88e5a63ee02a62020-11-24T21:20:03ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742012-01-0186e100275310.1371/journal.ppat.1002753The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.Nada AbdelmagidBiborka Bereczky-VeressAndré Ortlieb Guerreiro-CacaisPetra BergmanKatarina M LuhrTomas BergströmBirgit SköldenbergFredrik PiehlTomas OlssonMargarita DiezHerpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development.http://europepmc.org/articles/PMC3386237?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nada Abdelmagid Biborka Bereczky-Veress André Ortlieb Guerreiro-Cacais Petra Bergman Katarina M Luhr Tomas Bergström Birgit Sköldenberg Fredrik Piehl Tomas Olsson Margarita Diez |
spellingShingle |
Nada Abdelmagid Biborka Bereczky-Veress André Ortlieb Guerreiro-Cacais Petra Bergman Katarina M Luhr Tomas Bergström Birgit Sköldenberg Fredrik Piehl Tomas Olsson Margarita Diez The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. PLoS Pathogens |
author_facet |
Nada Abdelmagid Biborka Bereczky-Veress André Ortlieb Guerreiro-Cacais Petra Bergman Katarina M Luhr Tomas Bergström Birgit Sköldenberg Fredrik Piehl Tomas Olsson Margarita Diez |
author_sort |
Nada Abdelmagid |
title |
The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
title_short |
The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
title_full |
The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
title_fullStr |
The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
title_full_unstemmed |
The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
title_sort |
calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Pathogens |
issn |
1553-7366 1553-7374 |
publishDate |
2012-01-01 |
description |
Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development. |
url |
http://europepmc.org/articles/PMC3386237?pdf=render |
work_keys_str_mv |
AT nadaabdelmagid thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT biborkabereczkyveress thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT andreortliebguerreirocacais thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT petrabergman thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT katarinamluhr thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT tomasbergstrom thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT birgitskoldenberg thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT fredrikpiehl thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT tomasolsson thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT margaritadiez thecalcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT nadaabdelmagid calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT biborkabereczkyveress calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT andreortliebguerreirocacais calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT petrabergman calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT katarinamluhr calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT tomasbergstrom calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT birgitskoldenberg calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT fredrikpiehl calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT tomasolsson calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat AT margaritadiez calcitoninreceptorgeneisacandidateforregulationofsusceptibilitytoherpessimplextype1neuronalinfectionleadingtoencephalitisinrat |
_version_ |
1726004149587279872 |