Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF. cAMP signals are recei...

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Bibliographic Details
Main Authors: Gabriele G. Schiattarella, Nicola Boccella, Roberta Paolillo, Fabio Cattaneo, Valentina Trimarco, Anna Franzone, Stefania D’Apice, Giuseppe Giugliano, Laura Rinaldi, Domenica Borzacchiello, Alessandra Gentile, Assunta Lombardi, Antonio Feliciello, Giovanni Esposito, Cinzia Perrino
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
Subjects:
heart failure
Akt
cardiac hypertrophy
cardiomyocytes
pressure overload
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00558/full

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