The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation
The Atr-Check1 pathway is involved in cell cycle and the DNA damage response. Here, the authors show that the Atr-Check1 pathway can inhibit axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24131-7 |
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doaj-005c24fb0ae4423db9855a4fda43b7ac2021-06-27T11:13:23ZengNature Publishing GroupNature Communications2041-17232021-06-0112112010.1038/s41467-021-24131-7The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensationFeng Li0Tsz Y. Lo1Leann Miles2Qin Wang3Harun N. Noristani4Dan Li5Jingwen Niu6Shannon Trombley7Jessica I. Goldshteyn8Chuxi Wang9Shuchao Wang10Jingyun Qiu11Katarzyna Pogoda12Kalpana Mandal13Megan Brewster14Panteleimon Rompolas15Ye He16Paul A. Janmey17Gareth M. Thomas18Shuxin Li19Yuanquan Song20Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaThe Graduate Group in Biochemistry and Molecular Biophysics, University of PennsylvaniaRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of MedicineRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of MedicineRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaInstitute for Medicine and Engineering, University of PennsylvaniaInstitute for Medicine and Engineering, University of PennsylvaniaDepartment of Dermatology, University of PennsylvaniaDepartment of Dermatology, University of PennsylvaniaThe City University of New York, Graduate Center - Advanced Science Research Center, Neuroscience InitiativeInstitute for Medicine and Engineering, University of PennsylvaniaShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of MedicineShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of MedicineRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of PhiladelphiaThe Atr-Check1 pathway is involved in cell cycle and the DNA damage response. Here, the authors show that the Atr-Check1 pathway can inhibit axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery.https://doi.org/10.1038/s41467-021-24131-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Feng Li Tsz Y. Lo Leann Miles Qin Wang Harun N. Noristani Dan Li Jingwen Niu Shannon Trombley Jessica I. Goldshteyn Chuxi Wang Shuchao Wang Jingyun Qiu Katarzyna Pogoda Kalpana Mandal Megan Brewster Panteleimon Rompolas Ye He Paul A. Janmey Gareth M. Thomas Shuxin Li Yuanquan Song |
| spellingShingle |
Feng Li Tsz Y. Lo Leann Miles Qin Wang Harun N. Noristani Dan Li Jingwen Niu Shannon Trombley Jessica I. Goldshteyn Chuxi Wang Shuchao Wang Jingyun Qiu Katarzyna Pogoda Kalpana Mandal Megan Brewster Panteleimon Rompolas Ye He Paul A. Janmey Gareth M. Thomas Shuxin Li Yuanquan Song The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation Nature Communications |
| author_facet |
Feng Li Tsz Y. Lo Leann Miles Qin Wang Harun N. Noristani Dan Li Jingwen Niu Shannon Trombley Jessica I. Goldshteyn Chuxi Wang Shuchao Wang Jingyun Qiu Katarzyna Pogoda Kalpana Mandal Megan Brewster Panteleimon Rompolas Ye He Paul A. Janmey Gareth M. Thomas Shuxin Li Yuanquan Song |
| author_sort |
Feng Li |
| title |
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation |
| title_short |
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation |
| title_full |
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation |
| title_fullStr |
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation |
| title_full_unstemmed |
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation |
| title_sort |
atr-chek1 pathway inhibits axon regeneration in response to piezo-dependent mechanosensation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-06-01 |
| description |
The Atr-Check1 pathway is involved in cell cycle and the DNA damage response. Here, the authors show that the Atr-Check1 pathway can inhibit axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery. |
| url |
https://doi.org/10.1038/s41467-021-24131-7 |
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