Waldenström makroglobulinemili hastada rituksimab tedavisi sonrası gelişen gizli hepatit B reaktivasyonu

• Main Authors: Vedat Aslan, Aynur Albayrak, Emin Ediz Tutuncu, Harika Çelebi, Murat Albayrak
• Format: Article
• Language: English
• Published: Modestum Publishing LTD 2012-12-01
• Series: Journal of Clinical and Experimental Investigations
• Subjects: Waldenström’s macroglobulinemia; rituximab; occult HBV infection
• Online Access: http://www.jceionline.org/upload/sayi/11/JCEI-00492.pdf
• ISSN: 1309-8578; 1309-6621

The anti-CD20 monoclonal antibody rituximab has beenused extensively in the treatment of B-cell lymphoma.Several studies reported hepatitis B virus (HBV) reactivationafter rituximab. The majority of these cases havebeen described in chronic carriers of HBV, whereas reactivationin occult hepatitis B virus (OHBV) carriers mayoccur.The presented case with the diagnosis of Waldenström’smacroglobulinemia was HBsAg negative and anti HBcIgGpositive before chemotherapy. The patient was started onCVP (cyclophosphamide, vincristine, prednisolone) chemotherapy.However, no clinical or laboratory responsewas obtained and the patient was considered unresponsiveto three cycles of CVP therapy. Therefore R-CHOP(rituximab, cyclophosphamide, adriamycin, vincristineand prednisolone) was planned as the second therapy.Laboratory work-up after the first cycle of R-CHOP therapyrevealed an aspartate aminotransferase (AST) levelof 267 U/L and alanine aminotransferase (ALT) level of318 U/L. HBsAg and anti HBcIgG were positive and HBVDNA was 56400 IU/ml. Lamivudin 100 mg/day was started.Four weeks after the initiation of lamivudin therapy,ALT and AST levels returned to normal. Currently, the patienthas received the fourth cycle of R-CHOP therapy.ALT and AST levels continue to be in normal range. Thiscondition was considered to be the reactivation of OHBVfollowing rituximab.The aim of this case presentation is to call attention toHBV reactivation possibility in cases taking immunosupressivemedications like Rituximab. J Clin Exp Invest2012; 3(4): 541-544Key words: Waldenström’s macroglobulinemia, rituximab,occult HBV infection