Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

Abstract Background Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI) is unknown. Methods As part of a prospective observational study, enr...

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Bibliographic Details
Main Authors: Katherine Plewes, Hugh W.F. Kingston, Aniruddha Ghose, Richard J. Maude, M. Trent Herdman, Stije J. Leopold, Haruhiko Ishioka, Md. Mahtab Uddin Hasan, Md. Shafiul Haider, Shamsul Alam, Kim A. Piera, Prakaykaew Charunwatthana, Kamolrat Silamut, Tsin W. Yeo, Md. Abul Faiz, Sue J Lee, Mavuto Mukaka, Gareth D.H. Turner, Nicholas M. Anstey, L. Jackson Roberts, Nicholas J. White, Nicholas P.J. Day, Md. Amir Hossain, Arjen M. Dondorp
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Infectious Diseases
Subjects:
Acute kidney injury
Pathophysiology
Falciparum malaria
Cell-free hemoglobin
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s12879-017-2373-1

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