Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males
The Follicle-Stimulating Hormone plays an important role in the regulation of gametogenesis. It is synthesized and secreted as a family of glycoforms with differing oligosaccharide structure, biological action, and half-life. The presence of these oligosaccharides is absolutely necessary for the ful...
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doaj-006f257cf3c2469fbc66783c0b8cf2692020-11-24T21:16:23ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-01-011010.3389/fendo.2019.00017427976Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in MalesStella Campo0Luz Andreone1Verónica Ambao2Mariela Urrutia3Ricardo S. Calandra4Susana B. Rulli5Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE), Buenos Aires, ArgentinaCentro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE), Buenos Aires, ArgentinaCentro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE), Buenos Aires, ArgentinaCentro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE), Buenos Aires, ArgentinaInstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, ArgentinaInstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, ArgentinaThe Follicle-Stimulating Hormone plays an important role in the regulation of gametogenesis. It is synthesized and secreted as a family of glycoforms with differing oligosaccharide structure, biological action, and half-life. The presence of these oligosaccharides is absolutely necessary for the full expression of hormone bioactivity at the level of the target cell. The endocrine milieu modulates the glycosylation of this hormone. During male sexual development a progressive increase in FSH sialylation and in the proportion of glycoforms bearing complex oligosaccharides are the main features in this physiological condition. In late puberty, FSH oligosaccharides are largely processed in the medial- and trans-Golgi cisternae of the gonadotrope and remain without changes throughout adult life. In experimental models, the absence of gonads severely affects FSH sialylation; androgen administration is able to restore the characteristics observed under physiological conditions. The expression of ST6 beta-galactoside alpha-2,6-sialyltransferase 1 is hormonally regulated in the male rat; it decreases after short periods of castration but increases markedly at longer periods of androgen deprivation. Although ST3 beta-galactoside alpha-2,3-sialyltransferase 3 is expressed in the male rat pituitary it is not influenced by changes in the endocrine milieu. The oligosaccharide structure of FSH has an impact on the Sertoli cell endocrine activity. In more advanced stages of Sertoli cell maturation, both sialylation and complexity of the oligosaccharides are involved in the regulation of inhibin B production; moreover, FSH glycoforms bearing incomplete oligosaccharides may enhance the stimulatory effect exerted by gonadal growth factors. In this review, we discuss available information on variation of FSH glycosylation and its hormonal regulation under different physiological and experimental conditions, as well as the effect on Sertoli cell endocrine activity.https://www.frontiersin.org/article/10.3389/fendo.2019.00017/fullFollicle-stimulating hormone glycosylationhormonal regulationmale gonadSertoli cellinhibin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stella Campo Luz Andreone Verónica Ambao Mariela Urrutia Ricardo S. Calandra Susana B. Rulli |
spellingShingle |
Stella Campo Luz Andreone Verónica Ambao Mariela Urrutia Ricardo S. Calandra Susana B. Rulli Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males Frontiers in Endocrinology Follicle-stimulating hormone glycosylation hormonal regulation male gonad Sertoli cell inhibin |
author_facet |
Stella Campo Luz Andreone Verónica Ambao Mariela Urrutia Ricardo S. Calandra Susana B. Rulli |
author_sort |
Stella Campo |
title |
Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males |
title_short |
Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males |
title_full |
Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males |
title_fullStr |
Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males |
title_full_unstemmed |
Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males |
title_sort |
hormonal regulation of follicle-stimulating hormone glycosylation in males |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2019-01-01 |
description |
The Follicle-Stimulating Hormone plays an important role in the regulation of gametogenesis. It is synthesized and secreted as a family of glycoforms with differing oligosaccharide structure, biological action, and half-life. The presence of these oligosaccharides is absolutely necessary for the full expression of hormone bioactivity at the level of the target cell. The endocrine milieu modulates the glycosylation of this hormone. During male sexual development a progressive increase in FSH sialylation and in the proportion of glycoforms bearing complex oligosaccharides are the main features in this physiological condition. In late puberty, FSH oligosaccharides are largely processed in the medial- and trans-Golgi cisternae of the gonadotrope and remain without changes throughout adult life. In experimental models, the absence of gonads severely affects FSH sialylation; androgen administration is able to restore the characteristics observed under physiological conditions. The expression of ST6 beta-galactoside alpha-2,6-sialyltransferase 1 is hormonally regulated in the male rat; it decreases after short periods of castration but increases markedly at longer periods of androgen deprivation. Although ST3 beta-galactoside alpha-2,3-sialyltransferase 3 is expressed in the male rat pituitary it is not influenced by changes in the endocrine milieu. The oligosaccharide structure of FSH has an impact on the Sertoli cell endocrine activity. In more advanced stages of Sertoli cell maturation, both sialylation and complexity of the oligosaccharides are involved in the regulation of inhibin B production; moreover, FSH glycoforms bearing incomplete oligosaccharides may enhance the stimulatory effect exerted by gonadal growth factors. In this review, we discuss available information on variation of FSH glycosylation and its hormonal regulation under different physiological and experimental conditions, as well as the effect on Sertoli cell endocrine activity. |
topic |
Follicle-stimulating hormone glycosylation hormonal regulation male gonad Sertoli cell inhibin |
url |
https://www.frontiersin.org/article/10.3389/fendo.2019.00017/full |
work_keys_str_mv |
AT stellacampo hormonalregulationoffolliclestimulatinghormoneglycosylationinmales AT luzandreone hormonalregulationoffolliclestimulatinghormoneglycosylationinmales AT veronicaambao hormonalregulationoffolliclestimulatinghormoneglycosylationinmales AT marielaurrutia hormonalregulationoffolliclestimulatinghormoneglycosylationinmales AT ricardoscalandra hormonalregulationoffolliclestimulatinghormoneglycosylationinmales AT susanabrulli hormonalregulationoffolliclestimulatinghormoneglycosylationinmales |
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1726015692256313344 |