The relationship between fat mass and obesity-associated gene polymorphism and obesity among children in China: A systematic review and meta-analysis
The fat mass and obesity-associated (FTO) gene has been shown to be associated with obesity in different populations. However, this association in the Chinese population has been controversial. We evaluated the association of the FTO rs9939609 gene polymorphism with the risk of overweight and obesit...
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doaj-00858724185d4901ba29c92e81243ee22020-11-25T01:00:38ZengWolters Kluwer Medknow PublicationsInternational Journal of Noncommunicable Diseases2468-88272468-88352019-01-014410411410.4103/jncd.jncd_43_19The relationship between fat mass and obesity-associated gene polymorphism and obesity among children in China: A systematic review and meta-analysisZhiyong DongSheikh Mohammed Shariful IslamAshley M YuFaraz RaziRamit Kumar GuptaMohammad Ali MoniCunchuan WangThe fat mass and obesity-associated (FTO) gene has been shown to be associated with obesity in different populations. However, this association in the Chinese population has been controversial. We evaluated the association of the FTO rs9939609 gene polymorphism with the risk of overweight and obesity in Chinese children and adolescents in a systematic review and meta-analysis. We searched PubMed, Embase, Cochrane Library, and two electronic Chinese databases (CBM, CNKI). Two authors screened abstracts, full-texts, and extracted data according to the prespecified inclusion criteria. A modified STREGA score was used for quality assessment. A random-effects and fixed-effects model was used to conduct the measure the association between FTO gene and obesity. Ten studies including 12,879 participants were included. The FTO rs9939609 gene polymorphism was associated with a statistically significant increased risk of obesity or overweight in Han Chinese children and adolescents (P < 0.05), but absent in the Zhuang and Hazakh Chinese population (P > 0.05). The pooled OR for the codominant genetic model between AA and TT was 1.79 (95% confidence interval: 1.34–2.39, P < 0.0001). Allele A carriers were at greater risk of obesity and overweight compared to noncarriers. Screening for FTO rs9939609 gene polymorphism might help to identify adolescents at risk of developing obesity and consider appropriate prevention strategies.http://www.ijncd.org/article.asp?issn=2468-8827;year=2019;volume=4;issue=4;spage=104;epage=114;aulast=Dongfat mass and obesity associated genemeta-analysisobesityoverweightrs9939609 gene polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhiyong Dong Sheikh Mohammed Shariful Islam Ashley M Yu Faraz Razi Ramit Kumar Gupta Mohammad Ali Moni Cunchuan Wang |
spellingShingle |
Zhiyong Dong Sheikh Mohammed Shariful Islam Ashley M Yu Faraz Razi Ramit Kumar Gupta Mohammad Ali Moni Cunchuan Wang The relationship between fat mass and obesity-associated gene polymorphism and obesity among children in China: A systematic review and meta-analysis International Journal of Noncommunicable Diseases fat mass and obesity associated gene meta-analysis obesity overweight rs9939609 gene polymorphism |
author_facet |
Zhiyong Dong Sheikh Mohammed Shariful Islam Ashley M Yu Faraz Razi Ramit Kumar Gupta Mohammad Ali Moni Cunchuan Wang |
author_sort |
Zhiyong Dong |
title |
The relationship between fat mass and obesity-associated gene polymorphism and obesity among children in China: A systematic review and meta-analysis |
title_short |
The relationship between fat mass and obesity-associated gene polymorphism and obesity among children in China: A systematic review and meta-analysis |
title_full |
The relationship between fat mass and obesity-associated gene polymorphism and obesity among children in China: A systematic review and meta-analysis |
title_fullStr |
The relationship between fat mass and obesity-associated gene polymorphism and obesity among children in China: A systematic review and meta-analysis |
title_full_unstemmed |
The relationship between fat mass and obesity-associated gene polymorphism and obesity among children in China: A systematic review and meta-analysis |
title_sort |
relationship between fat mass and obesity-associated gene polymorphism and obesity among children in china: a systematic review and meta-analysis |
publisher |
Wolters Kluwer Medknow Publications |
series |
International Journal of Noncommunicable Diseases |
issn |
2468-8827 2468-8835 |
publishDate |
2019-01-01 |
description |
The fat mass and obesity-associated (FTO) gene has been shown to be associated with obesity in different populations. However, this association in the Chinese population has been controversial. We evaluated the association of the FTO rs9939609 gene polymorphism with the risk of overweight and obesity in Chinese children and adolescents in a systematic review and meta-analysis. We searched PubMed, Embase, Cochrane Library, and two electronic Chinese databases (CBM, CNKI). Two authors screened abstracts, full-texts, and extracted data according to the prespecified inclusion criteria. A modified STREGA score was used for quality assessment. A random-effects and fixed-effects model was used to conduct the measure the association between FTO gene and obesity. Ten studies including 12,879 participants were included. The FTO rs9939609 gene polymorphism was associated with a statistically significant increased risk of obesity or overweight in Han Chinese children and adolescents (P < 0.05), but absent in the Zhuang and Hazakh Chinese population (P > 0.05). The pooled OR for the codominant genetic model between AA and TT was 1.79 (95% confidence interval: 1.34–2.39, P < 0.0001). Allele A carriers were at greater risk of obesity and overweight compared to noncarriers. Screening for FTO rs9939609 gene polymorphism might help to identify adolescents at risk of developing obesity and consider appropriate prevention strategies. |
topic |
fat mass and obesity associated gene meta-analysis obesity overweight rs9939609 gene polymorphism |
url |
http://www.ijncd.org/article.asp?issn=2468-8827;year=2019;volume=4;issue=4;spage=104;epage=114;aulast=Dong |
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