Bimodal sensing of guidance cues in mechanically distinct microenvironments
Invasive cells respond to contact guidance cues during migration. Here, using micro- and nanopatterning with different ligands and varying stiffness, the authors find that cells can make cellular protrusions through both contractility-dependent and contractility-independent means.
Main Authors: | Erdem D. Tabdanov, Vikram V. Puram, Zaw Win, Ashab Alamgir, Patrick W. Alford, Paolo P. Provenzano |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-07290-y |
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