The Emerging Importance of Tumor Genomics in Operable Non-Small Cell Lung Cancer
During the last two decades, next-generation sequencing (NGS) has played a key role in enhancing non-small cell lung cancer treatment paradigms through the application of “targeted therapy” in advanced and metastatic disease. The use of specific tyrosine kinase inhibitors in patients with oncogenic...
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doaj-009e087fa24b4a8597b8a25199a62ab32021-08-06T15:20:02ZengMDPI AGCancers2072-66942021-07-01133656365610.3390/cancers13153656The Emerging Importance of Tumor Genomics in Operable Non-Small Cell Lung CancerHarry B. Lengel0James G. Connolly1Gregory D. Jones2Raul Caso3Jian Zhou4Francisco Sanchez-Vega5Brooke Mastrogiacomo6James M. Isbell7Bob T. Li8Yuan Liu9Natasha Rekhtman10David R. Jones11Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USAThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USAThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USAThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USADepartment of Surgery, Peking University, Beijing 100081, ChinaThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USAThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USAThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USADepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USAThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USADruckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USAThoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USADuring the last two decades, next-generation sequencing (NGS) has played a key role in enhancing non-small cell lung cancer treatment paradigms through the application of “targeted therapy” in advanced and metastatic disease. The use of specific tyrosine kinase inhibitors in patients with oncogenic driver alterations, such as <i>EGFR</i>, <i>ALK</i>, <i>ROS1</i>, <i>BRAF</i> V600E, <i>MET</i>, and <i>NTRK</i> mutations, among others, has changed treatment approaches and improved outcomes in patients with late-stage disease. Although NGS technology has mostly been used in the setting of systemic therapy to identify targets, response to therapy, and mechanisms of resistance, it has multiple potential applications for patients with earlier-stage disease, as well. In this review, we discuss the emerging role of NGS technologies to better understand tumor biology in patients with non-small cell lung cancer who are undergoing surgery with curative intent. In this patient cohort, we examine tumor heterogeneity, the underlying tumor genomics associated with lung adenocarcinoma subtypes, the prediction of recurrence after complete surgical resection, the use of plasma circulating tumor DNA for detection of early cancers and monitoring for minimal residual disease, the differentiation of separate primaries from intrapulmonary metastases, and the use of NGS to guide induction and adjuvant therapies.https://www.mdpi.com/2072-6694/13/15/3656next-generation sequencingsurgerylung cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Harry B. Lengel James G. Connolly Gregory D. Jones Raul Caso Jian Zhou Francisco Sanchez-Vega Brooke Mastrogiacomo James M. Isbell Bob T. Li Yuan Liu Natasha Rekhtman David R. Jones |
spellingShingle |
Harry B. Lengel James G. Connolly Gregory D. Jones Raul Caso Jian Zhou Francisco Sanchez-Vega Brooke Mastrogiacomo James M. Isbell Bob T. Li Yuan Liu Natasha Rekhtman David R. Jones The Emerging Importance of Tumor Genomics in Operable Non-Small Cell Lung Cancer Cancers next-generation sequencing surgery lung cancer |
author_facet |
Harry B. Lengel James G. Connolly Gregory D. Jones Raul Caso Jian Zhou Francisco Sanchez-Vega Brooke Mastrogiacomo James M. Isbell Bob T. Li Yuan Liu Natasha Rekhtman David R. Jones |
author_sort |
Harry B. Lengel |
title |
The Emerging Importance of Tumor Genomics in Operable Non-Small Cell Lung Cancer |
title_short |
The Emerging Importance of Tumor Genomics in Operable Non-Small Cell Lung Cancer |
title_full |
The Emerging Importance of Tumor Genomics in Operable Non-Small Cell Lung Cancer |
title_fullStr |
The Emerging Importance of Tumor Genomics in Operable Non-Small Cell Lung Cancer |
title_full_unstemmed |
The Emerging Importance of Tumor Genomics in Operable Non-Small Cell Lung Cancer |
title_sort |
emerging importance of tumor genomics in operable non-small cell lung cancer |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-07-01 |
description |
During the last two decades, next-generation sequencing (NGS) has played a key role in enhancing non-small cell lung cancer treatment paradigms through the application of “targeted therapy” in advanced and metastatic disease. The use of specific tyrosine kinase inhibitors in patients with oncogenic driver alterations, such as <i>EGFR</i>, <i>ALK</i>, <i>ROS1</i>, <i>BRAF</i> V600E, <i>MET</i>, and <i>NTRK</i> mutations, among others, has changed treatment approaches and improved outcomes in patients with late-stage disease. Although NGS technology has mostly been used in the setting of systemic therapy to identify targets, response to therapy, and mechanisms of resistance, it has multiple potential applications for patients with earlier-stage disease, as well. In this review, we discuss the emerging role of NGS technologies to better understand tumor biology in patients with non-small cell lung cancer who are undergoing surgery with curative intent. In this patient cohort, we examine tumor heterogeneity, the underlying tumor genomics associated with lung adenocarcinoma subtypes, the prediction of recurrence after complete surgical resection, the use of plasma circulating tumor DNA for detection of early cancers and monitoring for minimal residual disease, the differentiation of separate primaries from intrapulmonary metastases, and the use of NGS to guide induction and adjuvant therapies. |
topic |
next-generation sequencing surgery lung cancer |
url |
https://www.mdpi.com/2072-6694/13/15/3656 |
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