Expression differences of miR-142-5p between treatment-naïve chronic myeloid leukemia patients responding and non-responding to imatinib therapy suggest a link to oncogenic ABL2, SRI, cKIT and MCL1 signaling pathways critical for development of therapy resistance
Abstract Background Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by constitutive activity of the tyrosine kinase BCR-ABL1. Although the introduction of tyrosine kinase inhibitors (TKIs) has substantially improved patients’ prognosis, drug resistance remains one of th...
Main Authors: | Theresa Klümper, Henrike Bruckmueller, Tobias Diewock, Meike Kaehler, Sierk Haenisch, Christiane Pott, Oliver Bruhn, Ingolf Cascorbi |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-09-01
|
Series: | Experimental Hematology & Oncology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40164-020-00183-1 |
Similar Items
-
Patterns of microRNAs 142-3p, 106a, 17 and 20a expression in patients with systemic lupus erythematosus
by: Hecham Gamal AlDeen, et al.
Published: (2022-01-01) -
SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients
by: Sierk Haenisch, et al.
Published: (2015-05-01) -
Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction
by: Manish Muhuri, et al.
Published: (2021-04-01) -
Analysis of MicroRNA Expression Changes During the Course of Therapy In Rectal Cancer Patients
by: Klara Cervena, et al.
Published: (2021-09-01) -
Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis
by: Anquan Shang, et al.
Published: (2020-07-01)