The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells.

The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells.

Oxadiazines are heterocyclic compounds containing N-N-O or N-N-C-O system within a six membered ring. These structures have been up to now exclusively prepared via organic synthesis. Here, we report the discovery of a natural oxadiazine nocuolin A (NoA) that has a unique structure based on 1,2,3-oxa...

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Bibliographic Details
Main Authors: Kateřina Voráčová, Jan Hájek, Jan Mareš, Petra Urajová, Marek Kuzma, José Cheel, Andreas Villunger, Alexandra Kapuscik, Marcel Bally, Petr Novák, Martin Kabeláč, Gerhard Krumschnabel, Martin Lukeš, Ludmila Voloshko, Jiří Kopecký, Pavel Hrouzek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5333925?pdf=render

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