Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients

Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients

The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cell...

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Bibliographic Details
Main Authors: Kaat de Jonge, Laure Tillé, Joao Lourenco, Hélène Maby-El Hajjami, Sina Nassiri, Julien Racle, David Gfeller, Mauro Delorenzi, Grégory Verdeil, Petra Baumgaertner, Daniel E. Speiser
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
b cells
tumor microenvironment
immune checkpoint
melanoma
inflammation
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1873585

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