Differential distribution of age and HBV serological markers in liver cirrhosis and non-cirrhotic patients with primary liver cancer

• Main Author: XU Xiuhua
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2013-03-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: liver neoplasms; liver cirrhosis; hepatitis B; chronic; hepatitis B virus
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=5274&ClassID=21135430

ObjectiveTo compare the age distributions and presence of hepatitis B virus (HBV) serological markers between primary hepatic cancer (PHC) patients with and without liver cirrhosis. MethodsA total of 547 PHC cases were analyzed retrospectively. After dividing into two groups according to liver cirrhosis status, the between-group differences in age and HBV serological markers, such as hepatitis B e antigen (HBeAg) status, were statistically compared using the Chi-squared test. ResultsThe number of cirrhotic and non-cirrhotic PHC patients was 265 and 282, respectively. HBV infection was present in 221 cirrhotic PHC patients and 256 non-cirrhotic PHC patients (834% vs. 90.8%). There was a substantial bias in the proportion of males to females in the cirrhotic PHC patients (7.83∶1). The number of PHC patients ＜60 years old was similar between the cirrhotic and non-cirrhotic groups, but the non-cirrhotic group had significantly more patients ＞60 years old (P＜0.005). In cirrhotic PHC patients, the HBV infection rate was highest in the ＜40 years old age group (96.7%) and the HBeAg serological conversion rate was highest in the 40-60 years old age group (89.5%). In non-cirrhotic PHC patients, the 40-60 years old age group showed the highest HBV infection rate (90.3%) but the lowest HBeAg serological conversion rate (80.0%). ConclusionPHC with liver cirrhosis mainly occurred in males, with the HBV infection rate being higher in individuals ＜60 years old. Non-cirrhotic PHC patients were more often ＞60 years old. Many of the HBV-infected PHC patients with cirrhosis had high HBeAg serological conversion rate.