Systematic Analysis of Whole Exome Sequencing Determines RET G691S Polymorphism as Germline Variant in Melanoma

Systematic Analysis of Whole Exome Sequencing Determines RET G691S Polymorphism as Germline Variant in Melanoma

The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by glial cell derived neutrotrophic factor (GDNF). Previous studies have found that a single nucleotide polymorphism (SNP), RETp (G691S), in the juxtamembrane domain enhances the signaling pathway and promotes tumor growth b...

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Bibliographic Details
Main Authors: Brent J. Smith Jr, Jennifer D. Hintzsche, Carol M. Amato, Aik-Choon Tan, Keith R. Wells, Allison J. Applegate, Rita T. Gonzalez, Jodie R. Barr, William A. Robinson
Format: Article
Language:English
Published: Marshall University 2017-04-01
Series:Marshall Journal of Medicine
Subjects:
RETp
G691S
melanoma
whole exome sequencing
germline variant
Online Access:https://mds.marshall.edu/cgi/viewcontent.cgi?article=1119&context=mjm

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