In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels
Background: Patients with chronic spontaneous urticaria often exhibit psychiatric comorbidities including depression that contribute to the impairment of their quality of life. How CSU and depression are linked isn't well-understood. Substance P has been shown to be increased in patients with C...
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doaj-00dc978c4e2f4feea3d13aa5edef67bd2021-05-26T04:23:58ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-05-011210.3389/fpsyt.2021.667978667978In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P LevelsBachar Memet0Eren Vurgun1Fatma Barlas2Martin Metz3Marcus Maurer4Emek Kocatürk5Department of Dermatology, Koç University School of Medicine, Istanbul, TurkeyDepartment of Medical Biochemistry, Okmeydani Training and Research Hospital, Istanbul, TurkeyDepartment of Psychiatry, Okmeydani Training and Research Hospital, Istanbul, TurkeyDermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité—Universitätsmedizin Berlin, Berlin, GermanyDermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité—Universitätsmedizin Berlin, Berlin, GermanyDepartment of Dermatology, Koç University School of Medicine, Istanbul, TurkeyBackground: Patients with chronic spontaneous urticaria often exhibit psychiatric comorbidities including depression that contribute to the impairment of their quality of life. How CSU and depression are linked isn't well-understood. Substance P has been shown to be increased in patients with CSU and is held to contribute to the pathogenesis of depression.Methods: We measured disease activity in 30 CSU patients without depression and 30 CSU patients with depression by using the urticaria activity score. The severity of depression was assessed with the Beck Depression Inventory. We measured SP levels in these patients as well as in 30 healthy control subjects. In patients with comorbid depression, we correlated SP levels with CSU disease activity and the severity of depression.Results: In CSU patients, disease activity and the severity of depression were positively linked. UAS7 values were higher in CSU patients with comorbid depression as compared to those without (p < 0.05). SP levels were higher in CSU patients with depression than in those without (p < 0.001), but was similar in all CSU patients compared to healthy controls. SP levels weren't correlated with UAS7 values in CSU patients with depression, whereas they were weakly but significantly correlated with BDI scores (p < 0.05).Conclusion: Our results suggest that, in CSU patients with comorbid depression, CSU disease activity affects the severity of depression. CSU patients with high disease activity should be explored for comorbid depression.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.667978/fullurticariadepressionsubstance-Ppathogenesispsychiatric disorders |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bachar Memet Eren Vurgun Fatma Barlas Martin Metz Marcus Maurer Emek Kocatürk |
spellingShingle |
Bachar Memet Eren Vurgun Fatma Barlas Martin Metz Marcus Maurer Emek Kocatürk In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels Frontiers in Psychiatry urticaria depression substance-P pathogenesis psychiatric disorders |
author_facet |
Bachar Memet Eren Vurgun Fatma Barlas Martin Metz Marcus Maurer Emek Kocatürk |
author_sort |
Bachar Memet |
title |
In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels |
title_short |
In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels |
title_full |
In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels |
title_fullStr |
In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels |
title_full_unstemmed |
In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels |
title_sort |
in chronic spontaneous urticaria, comorbid depression linked to higher disease activity, and substance p levels |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2021-05-01 |
description |
Background: Patients with chronic spontaneous urticaria often exhibit psychiatric comorbidities including depression that contribute to the impairment of their quality of life. How CSU and depression are linked isn't well-understood. Substance P has been shown to be increased in patients with CSU and is held to contribute to the pathogenesis of depression.Methods: We measured disease activity in 30 CSU patients without depression and 30 CSU patients with depression by using the urticaria activity score. The severity of depression was assessed with the Beck Depression Inventory. We measured SP levels in these patients as well as in 30 healthy control subjects. In patients with comorbid depression, we correlated SP levels with CSU disease activity and the severity of depression.Results: In CSU patients, disease activity and the severity of depression were positively linked. UAS7 values were higher in CSU patients with comorbid depression as compared to those without (p < 0.05). SP levels were higher in CSU patients with depression than in those without (p < 0.001), but was similar in all CSU patients compared to healthy controls. SP levels weren't correlated with UAS7 values in CSU patients with depression, whereas they were weakly but significantly correlated with BDI scores (p < 0.05).Conclusion: Our results suggest that, in CSU patients with comorbid depression, CSU disease activity affects the severity of depression. CSU patients with high disease activity should be explored for comorbid depression. |
topic |
urticaria depression substance-P pathogenesis psychiatric disorders |
url |
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.667978/full |
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